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Semaglutide User Reviews & Ratings

Brand names: Ozempic, Wegovy, Rybelsus

Semaglutide has an average rating of 6.6 out of 10 from a total of 2,024 reviews on Drugs.com. 54% of reviewers reported a positive experience, while 24% reported a negative experience.

Reviews for Semaglutide

  • jwillou
  • Taken for less than 1 month
  • February 27, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I have been taking Wegovy for 1 week and 2 days. Only had the 0.25 dosage. I have had no side effects and I have lost 8 lbs. I am hoping as I increase the dosage I remain free of side effects and the weight continues to fall off. I will continue to leave feedback so people can see how it is working and hopefully it will help them make a decision. I almost didn't go through with the first injection because of all the negative reviews. I am glad that I did give it a try. If I start to get nasty side effects, I will ask my doctor if I can stay at the dosage prior where there were none. I am wanting to lose 100 lbs. I started at 250 @ 5'4". So far, I am extremely happy!"

10 / 10
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  • dana
  • Taken for less than 1 month
  • September 26, 2020

Ozempic (semaglutide) "Started taking this medication off label for weight loss only. I am not diabetic. Started on Aug 30, 2020. First 2 weeks I had some mild nausea, nothing terrible, and some mild dizziness. The past 2 weeks, I have had no symptoms. I definitely cannot eat what I used to, or you will feel sick. I am doing the weekly injection at 0.25 along with Weight Watchers, and in the past 26 days, I have lost 10.5 lbs :). My sweet tooth cravings are pretty much gone. Really happy so far. I am increasing to 0.50mg next week. I'll keep you all posted!"

9 / 10
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  • Smithy...
  • Taken for 1 to 6 months
  • March 14, 2023

Ozempic (semaglutide) for Weight Loss (Obesity/Overweight) "I was hesitant to try Ozempic for weight loss (need to lose 30 lbs) because I have a lot of kids/responsibilities and don't have the time to be nauseous or have debilitating diarrhea, etc. After keeping the pen in the fridge for weeks, I decided to risk an injection, and I'm so happy to say I've had zero side effects except a disinterest in food. I'm on week six of the 0.25 dose because it's enough for me, and I don't see a reason to increase the dose. My lack of interest in food is liberating! For the first time in 30 years, I don't go to bed kicking myself for what I've eaten or making promises to myself to make amends for overeating. Zero sugar cravings...food isn't a reward or pleasure anymore. I'm never ravenous, so I make good, calm choices about what I eat. This has been life-changing and a complete shift in perspective. Obviously, some people have terrible side effects, but I've had none (not even a headache!)."

10 / 10
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Frequently asked questions

  • Philly
  • Taken for 6 months to 1 year
  • February 6, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "6 months. -65 pounds. Hypertension gone. Pre-Diabetes gone. Sleep apnea gone. Lower leg skin breakdown gone. Slow progress now. I must fight the return of old eating habits. Wegovy is not for wimps. But if you really want to lose weight, this is the way to go. This is like bariatric surgery in a small needle."

10 / 10
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  • Lovew...
  • Taken for 1 to 2 years
  • November 5, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I started at a size XXL/pants size 16 and 213 lbs. After a little over a year, I am now 125 lbs and a size small/pants size 2. This drug literally reset my entire body chemistry and metabolism. I never dieted nor exercised the past year. I don’t want to lose any more weight, so I just went down to a 1 mg half dose to maintain my weight loss. I am so grateful for this medicine!"

10 / 10
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Are you taking this medicine?

  • Zell
  • Taken for 6 months to 1 year
  • March 29, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "I started Ozempic 9 months ago. At the time, I was a little over 200 lbs and was taking 1000 mg of metformin daily. Metformin had worked for me for almost 20 years, so I didn't expect that it had suddenly stopped working. For 3 years, I gained weight even though I worked out, and I thought it was just my appetite out of control. One random day, I realized my metformin was the problem. I saw a new doctor who prescribed Ozempic. What a miracle! 9 months later, and I’m down 40 lbs, my A1C dropped from 8.1 to 5.6, and I have virtually no symptoms from the drug other than fullness. The symptoms in the beginning did not last long either. Nausea, headache, fatigue...all cleared up within a week or 2 each time my dose was increased. It can cause what feels like constipation, but for me, it’s just that I simply haven’t eaten enough. This drug feels too good to be true. I’m so pleased with my experience so far!"

10 / 10
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  • Slow...
  • Taken for 1 to 6 months
  • April 3, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Starting week 9 with the second injection of 1 mg. I have lost 24 pounds in 8 weeks. The side effects happen about 3 - 4 days a week. The first weekend on 0.25 mg was the worst! I really thought I needed my last rites! I have had headaches, nausea, vomiting, and bowel issues but not like the first-week episode. I try to eat light the day of the shot and take it at night because it makes me tired. You have to stay positive and just buy meds that will help with side effects because the side effects will probably always happen a couple of days a week. Try to drink 1/2 gallon of water a day and stay away from red meat, fried food, fast food, (most) dairy and sugar. If you don't, you will feel sick from eating that stuff. Also only eating one cup of food every couple of hours has made a huge difference in the nausea. Stock up on SF ice pops and SF Gatorade. I am so grateful that I got Wegovy with my insurance and when I want to quit, I just remember how many people would love the opportunity."

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More FAQ

  • Stingie
  • Taken for less than 1 month
  • July 21, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "I did one injection and have been ill since. I have had acid reflux, burping, vomiting, constipation, headache, and dizziness. I tried to eat small meals and drink plenty of water as directed by my physician, but I have been unable to hold anything down. Five days after my first injection, I'm off work, drinking Pedialyte, trying to get my strength back, and avoid being hospitalized. This is the worst that I have ever felt in my life."

1 / 10
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  • Teresa
  • September 6, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "I’ve been on Ozempic for 4 weeks. I am so glad that my doctor sat me down and told me what to expect. She also asked if I could handle it. She said that if you can make it through the 4th week, I promise it will get better. She was right. I was pretty sick the first two weeks. I learned that it had a lot to do with me trying to eat my normal intake of food. Once I started to catch a clue and make my portions smaller, I learned it would make me feel better. I could guarantee if I ate too much, I’d feel like crap. People aren’t kidding about the side effects. It’s real. But I made it and am now starting to feel better with each day. I’ve lost 18 pounds now and I’m amazed. Yes, it makes you sick, but if you keep trying to eat like you did, it will be worse. You have to start listening to your body. You can’t keep eating your same amounts and expect to lose weight."

10 / 10
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  • KS in...
  • Taken for 1 to 6 months
  • April 18, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Tomorrow I will take my 3rd shot of 0.5 mg (previously took 3 weeks of 0.25 mg but messed up one of the needles, so moved up after only 3 weeks at that amount). I have had very minimal side effects in the 5 weeks I've been on it (lost 9.5 pounds). The side effects I get are headaches if I don't drink enough water - WATER IS KEY - and nausea if I don't eat enough protein. Five small protein-based meals a day seem to do the trick. Have not suffered any of the other things people talk about. I've noticed my clothes are more loose fitting than a 9-pound weight loss would normally warrant. Everyone is different - and people tend to post complaints more than praises... so don't get too stressed assuming you'll have side effects. Most people don't. I'm glad I'm on this journey."

10 / 10
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  • KJF
  • Taken for 1 to 6 months
  • September 19, 2021

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I am currently on my 9th injection today, being my 8th full week being on Wegovy. I have lost a total of 40 pounds so far. Appetite is definitely curbed. Sundays when I take the injection, it makes me tired. A lot of gas and the occasional runs, but the weight loss is worth the side effects."

9 / 10
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  • LCMel
  • Taken for 1 to 6 months
  • March 18, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "Wegovy has absolutely curbed my appetite at the 0.25 dose. I definitely do not feel nearly as hungry as I used to. I will eat maybe 1/3 to 1/2 of what used to be a normal portion for me and get signals to stop. It has not made me sick at all, unlike other reviews. I think it's a real godsend for me with COVID and menopausal weight gain."

10 / 10
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  • MzGormo
  • Taken for 1 to 6 months
  • January 30, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "Started on Ozempic in September 2020, starting weight 312 lbs (5’4”). I am type 2 diabetic and take 2550mg of Metformin daily. HbA1c was 79, sugar cravings, and blood sugar out of control. Started on 0.25 dose for a month. Quite bad stomach cramps and nausea for the first month. Went up to 0.5 dose in month 2, then 1.0 dose for month 3 and since. No. 1 tip - inject into your leg rather than around your belly. Once I changed to injecting in my leg, nausea and cramps disappeared overnight, and never came back. To maximize effectiveness, you can’t eat like you did before. I re-joined Weight Watchers in September. I have lost 80 lbs in 5 months, HbA1c dropped from 79 to 51 which is a normal type 2 level although the doc feels with more weight loss, it could go to normal levels. In Ireland, diabetes is classed as a long-term illness so all medications are covered by the government, so I don’t have to pay for this. Otherwise, it costs €195."

10 / 10
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  • Daisy...
  • Taken for less than 1 month
  • January 23, 2023

Rybelsus (semaglutide) "I wanted to write this early in the process of taking this medication because I know how it feels to be scared to take this tablet. I’m on it for weight loss in the UK cost £139. I read a tip to take it early in the morning, I usually take it between 4 am-6 am. I started taking it 2 days ago. The first day I felt fine with no side effects, the second day I was feeling a bit nauseous but it was manageable. Today my appetite has decreased already and I only want small amounts to eat, the thought of a large meal makes me feel ill. I’m intrigued to know if this will stay or go. If it lasts I will be one of the lucky ones. I weigh about 268 lbs so I will come back in two weeks and let you know. I hope the side effects don’t ramp up each day I take it. We will see."

8 / 10
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  • Doubt...
  • January 19, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "I took one Ozempic injection at 0.25 and ended up at the ER 2 days later. I had horrible bloating. Burping smelled like eggs. Unstoppable vomiting and diarrhea. I ONLY TOOK ONE INJECTION and stopped the medicine. It has been 2 weeks and the medicine is still making me sick. I'm just wondering how long it takes to fully leave your system? I just want to feel human again. I was tested for pancreatitis but was okay, but the doctor said they will repeat labs soon. I DON'T RECOMMEND THIS MEDICATION TO ANYONE. PLEASE BE SAFE TAKING THIS MEDICATION."

1 / 10
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  • Susie...
  • Taken for 6 months to 1 year
  • July 14, 2021

Ozempic (semaglutide) for Cardiovascular Risk Reduction "I have been on Ozempic for exactly 1 year as my insulin intake (injection) was far too high, as well as Metformin. I was asked if I wanted to try Ozempic and was told that it may help with weight loss too. In the course of the year, I have lost over 9 stone in weight and gone from a ladies size 26 in clothing to a size 14 to 16. I have never been happier with my weight, my blood sugars are normal levels now which they were previously out of control."

10 / 10
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  • Mary
  • March 6, 2021

Ozempic (semaglutide) for Cardiovascular Risk Reduction "I was prescribed it for prediabetes and weight loss. Today, in one week since my first injection, I lost 6 lbs. In one week, the last diet (one of very many), it took me 3 months to lose 10 lbs by starving myself, which tells you how elevated sugar prevents you from losing weight. I am not diabetic, my A1C is 5.5. I had slight nausea and fatigue the first 2 days, and after that, it’s all gone and I never felt better. I have no cravings. I eat approximately 1000 calories a day, and it’s more than enough. Instead of constant thoughts of food, I do other things that I used to enjoy like exercise, etc. I am worried about coming off Ozempic before I lose all the weight I need. It is a miracle drug for me! I hope it will help you all! If they keep working on meds like this, it will reduce type 2 diabetes and obesity drastically."

10 / 10
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  • Kmac
  • Taken for 1 to 6 months
  • January 10, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "First of all, this does work. I lost over ten pounds in 6 weeks. The weight just fell off. Second of all, this was the worst experience I have ever had with a prescribed medication. Well, I started at the lowest dose and took that for 4 weeks before moving to the next dose, which I believe was 0.5 mg. The maintenance dose is 2.4 mg, I believe. How anyone makes it to the 2.4 mg is beyond me. I made it to the second dose of 0.5 mg before I threw in the towel. This stuff is WICKED. I spent 6 weeks of my life with an upset stomach, the absolute worst reflux and heartburn I have ever had, and constant nausea. I had to literally force myself to eat. Would not recommend. The side effects and the price are not worth it. Easy to lose weight when you are starving yourself and feel too sick to eat. Once I stopped, it took a few days to feel better and the weight came back lightening quick plus a few. Not worth the misery in my opinion."

1 / 10
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  • Backt...
  • Taken for 1 to 6 months
  • March 9, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I started Wegovy 6 weeks ago at 0.25 mg for 4 weeks, and for the last 2 weeks at 1 mg. I started at 211 lbs and am now 197 lbs, so have lost 14 lbs and counting in 6 weeks. Not bad! Symptoms I've experienced include being slightly more tired than usual on the day of the injection, and some constipation at first but I use Miralax if there's an issue and it works fine for me. I haven't had any extreme nausea, but the injection definitely makes me less hungry and there are certain foods that I feel slightly queasy even considering eating—like high-fat foods—so I don't eat them. I eat a lot more fruits and vegetables and get full very quickly. I work out 4-5 days a week, my energy has been good and I feel like I'm getting back to my old self. I'd like to be about 135 lbs eventually. Wegovy has been a lifesaver. I'm 55 years old and had considerable cravings, especially at night. I'm happy to be free of them. I hope to make my new habits permanent."

10 / 10
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  • Mac
  • October 18, 2020

Ozempic (semaglutide) for Diabetes, Type 2 "Ozempic has caused me so much constipation!!! I know a side effect is diarrhea, but it does the complete OPPOSITE for me. A day or two after I take my injection, I have no bowel movements at all!! Every week I am forced to take a laxative. It has caused so many problems for me. Anyone else experienced severe constipation. So frustrated."

1 / 10
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  • Goodbye...
  • Taken for 6 months to 1 year
  • May 2, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I started Ozempic last June. I switched to Wegovy in September. My starting weight was 216.8 pounds at 5’6”, and I’m a 50-year-old post-menopausal woman. In 9 months, I’m down to 148.2 pounds (-68 lbs; almost 35%), and went from a size 16 to a size 8. Could only take 1.0 due to kidneys not functioning normally when upped to 1.7. I do not have time to work out. I thought it would be hard to give myself a shot, but it’s so easy! Absolutely amazing! Side effects are limited appetite and sleep (especially the first couple of days after the shot), nausea (especially when brushing teeth or smelling things), and hair loss (started more around month 6). But no other diet worked after menopause and stress for over 10 years. I love my new body (something I have NEVER said)! Will stay on it forever! Excited for warmer weather and outside activities (and the strength to do things)!"

10 / 10
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  • Julie
  • Taken for less than 1 month
  • March 20, 2023

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I've been on Wegovy for 3 weeks now. My biggest regret is that I let the negative reviews scare me from taking it for about 4 weeks. I finally decided to just do it and boy am I glad I did! This stuff is magic! It has completely curbed my appetite, and I have had a few side effects - mostly a metallic taste in my mouth and increased thirst. Some very minor stomach upset but nothing that can't be dealt with. I have definitely lost weight but I'm not keeping track yet. I started with a 0.25 mg dose and will move to the 0.5 mg dose after the 4th week. If you're worried about side effects, just know that it's different for everyone, and you won't know what your experience will be like until you try it."

10 / 10
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  • Kitkat
  • Taken for 1 to 6 months
  • July 20, 2021

Ozempic (semaglutide) for Diabetes, Type 2 "I'm a 54-year-old female whose A1C was 8.3 at the end of March. So, after 4 months on Ozempic, my A1C is now 6.3, and I've lost 34 lbs. Definitely curbs my appetite, and I have been logging my food. My side effects have been minimal - a little nausea in the beginning and constipation. This med has been a game-changer for me. My hope is that many others will have the same results I have."

10 / 10
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  • Jenni...
  • Taken for 1 to 6 months
  • April 1, 2023

Ozempic (semaglutide) for Weight Loss (Obesity/Overweight) "I started Ozempic on 2/22/23 weighing 216 lbs. As of today, 4/1/2023, I am 191.2 lbs, so just about 25 lbs in 5.5 weeks! I started out at 0.25 for 4 weeks, then moved to 0.5 last week. I've been nauseous maybe 4 times, I’ve gotten a few headaches, and kinda backed up about 3 days a week. I started taking magnesium at night before bed, and that really helped me get more regular. I’m barely hungry and need to force myself to eat. Anyways, I’m really excited and I’m looking forward to summer!"

10 / 10
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  • Wegovy...
  • Taken for 1 to 6 months
  • February 8, 2022

Wegovy (semaglutide) for Weight Loss (Obesity/Overweight) "I'm in my second week of the 2.4 mg dose of Wegovy. A lot of folks who posted mentioned cramps and nausea. I would usually experience this the first day and second day of injections early on but not so much now in the 2.4 mg dose. The cure for the nausea that worked best for me was a couple bouillon cubes. Did the trick every time. Ate high protein and low carbs. Increased salads, which are a key component of doing well with Wegovy and a low carb/high protein diet. I had gastric bypass in 2011 and lost quite a bit of weight, which I kept off for a while, but gained almost all of it back through Covid and began Wegovy in October 2021. As of today, I have lost 67 lbs, which is absolutely amazing. I am rehabbing for a knee replacement, and this has been the absolute missing piece. This has removed all cravings for food, alcohol, and most other things. My dosing day is Tuesday mornings, and I can really tell on Monday afternoon/night as I start to get those cravings! Make good choices!"

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.