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User Reviews for Semaglutide

Also known as: Ozempic, Rybelsus, Wegovy

Semaglutide has an average rating of 6.0 out of 10 from a total of 1,012 ratings on Drugs.com. 46% of reviewers reported a positive experience, while 34% reported a negative experience.

Condition Avg. Rating Reviews Compare
Diabetes, Type 2  
5.7
706 reviews 152 medications
Cardiovascular Risk Reduction  
6.6
164 reviews 18 medications
Obesity  
6.6
142 reviews 66 medications
Summary of Semaglutide reviews 6.0 1,012 reviews

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Semaglutide

dana · Taken for less than 1 month · September 26, 2020

Ozempic (semaglutide): “Started taking this medication off label for weight loss only, I am not diabetic. Started on Aug 30, 2020. First 2 weeks I had some mild nausea nothing terrible and some mild dizziness, the past 2 weeks I have had no symptoms. I definitely cannot eat what I use to or you will feel sick. I am doing the weekly injection at 0.25 along with weight watchers and in the past 26 days I have lost 10.5 lbs :). My sweet tooth cravings are pretty much gone. Really happy so far, I am increasing to 0.50mg next week. I'll keep you all posted!”

9 / 10
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Zell · Taken for 6 months to 1 year · March 29, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “I started ozempic 9 months ago. At the time I was a little over 200 lbs and was taking 1000 mg of metformin daily. Metformin had worked for me for almost 20 yrs so I didn't expect that is had suddenly stopped working. For 3 years I gained weight even though I worked out, and I thought it was just my appetite out of control. One random day I realized my metformin was the problem. I saw a new dr who prescribed ozempic. What a miracle! 9 months later and I’m down 40 lbs, my a1c dropped from 8.1 to 5.6, and I have virtually no symptoms from the drug other than fullness. The symptoms in the beginning did not last long either. Nausea, headache, fatigue...all cleared up within a week or 2 each time my dose was increased. It can cause what feels like constipation but for me it’s just that I simply haven’t eaten enough. This drug feels too good to be true. I’m so pleased with my experience so far!”

10 / 10
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Teresa · September 6, 2020

Ozempic (semaglutide) for Diabetes, Type 2: “I’ve been Ozempic for 4 weeks. I am so glad that my doctor sat me down and told me what to expect. She also asked if I could handle it. She said that if you can make it through the 4th week I promise it will get better. She was right. I was pretty sick the first two weeks. I learned that it had a lot to do with me trying to eat my normal intake of food. Once I started to catch a clue and making my portions smaller, I learned it would make me feel better. I could guarantee if I ate too much, I’d feel like crap. People aren’t kidding about the side effects. It’s real. But I made it and am now starting to feel better with each day. I’ve lost 18 pounds now and I’m amazed. Yes it makes you sick but if you keep trying to eat like you did it will be worse. You have to start listening to your body You can’t keep eating your same amounts and expect to lose weight.”

10 / 10
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Stingie · Taken for less than 1 month · July 21, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “I did one injection and have been ill since. Have had acid reflux, burping, vomiting, constipation, headache and dizziness. I tried to eat small meals and drink plenty of water as directed by my physician, but I have been unable to hold anything down. 5 days after my first injection, I'm off work drinking pedialyte trying to get my strength back and avoid being hospitalized. This is the worst that I have ever felt in my life.”

1 / 10
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MzGormo · Taken for 1 to 6 months · January 30, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “Started on Ozempic Sept 2020, starting weight 312 lbs (5’ 4”). I am type 2 diabetic and take 2550mg of Metformin daily. HbA1c was 79, sugar cravings and blood sugar out of control. Started on 0.25 dose, for a month. Quite bad stomach cramps and nausea for the first month. Went up to 0.5 on month 2, then 1.0 dose for month 3 and since. No 1 tip - inject into your leg rather than around your belly. Once I changed to injecting in my leg, nausea and cramps disappeared overnight & never came back. To maximise effectiveness, you can’t eat like you did before. I re-joined Weight Watchers in Sept. I have lost 80lbs in 5 months, HBA1c dropped from 79 to 51 which is normal type 2 level although the doc feels with more weight loss, it could go to normal levels. In Ireland, diabetes is classed as a long term illness so all medications are covered by the government so I don’t have to pay for this. Otherwise costs €195.”

10 / 10
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Philly · Taken for 6 months to 1 year · February 6, 2022

Wegovy (semaglutide) for Obesity: “6 months. -65 pounds. Hypertension gone. Pre Diabetes gone. Sleep apnea gone. Lower leg skin breakdown gone. Slow progress now. I must fight return of old eating habits. Wegovy is not for wimps. But if you really want to lose weight, this is the way to go. This is like bariatric surgery in a small needle.”

10 / 10
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Susieblee · Taken for 6 months to 1 year · July 14, 2021

Ozempic (semaglutide) for Cardiovascular Risk Reduction: “I have been on ozempic for exactly 1 year as my insulin intake (injection) was far too high as well as Metformin. I was asked if I wanted to try ozempic and was told that it may help with weight loss too. In the course of the year I have lost over 9 stone in weight and gone from a ladies size 26 in clothing to a size 14 to 16. I have never been happier with my weight, my blood sugars are normal levels now which they were previously out of control.”

10 / 10
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Frequently asked questions

Kitkat · Taken for 1 to 6 months · July 20, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “I'm a 54 year old female who's a1c was 8.3 at the end of March. So after 4 months on Ozempic, my a1c is now 6.3! and I've lost 34 lbs. Definitely curbs my appetite and I have been logging my food. My side effects have been minimal, a little nausea in the beginning and constipation. This med has been a game changer for me. My hope I that many others will have the same results I have.”

10 / 10
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Mary · March 6, 2021

Ozempic (semaglutide) for Cardiovascular Risk Reduction: “I was prescribed it for prediabetes and weight loss. Today in one week since my first injection and I lost 6 lbs....in one week, last diet (one of very many) it took me 3 month to lose 10 lb by starving myself, which tells you how elevated sugar prevents you to lose weight. I am not diabetic, my a1c 5.5. I has slight nausea and fatigue first 2 days and after that, it’s all gone and I never felt better, I have no cravings, I eat approximately 1000cal. A day and it’s more than enough, instead of contact thoughts of food I do other things that I USED to enjoy: exercise, etc. I am worried coming off ozempic before I lose all weight I need. It is a miracle drug for me! I hope it will help you all! If they keep working on meds like this it will reduce DT2 and obesity drastically”

10 / 10
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Doubtful · January 19, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “I took one Ozempic injection at .25 and ended up at ER 2 days later. I had horrible bloating. Burping smelled like eggs. Unstoppable vomiting and diarrhea. I ONLY TOOK ONE INJECTION and stopped the medicine. It has been 2 weeks and the medicine still making me sick. I'm just wondering how long it takes to fully leave your system? I just want to feel human again. I was tested for pancreatitis but was ok but dr said will repeat labs soon. I DON'T RECOMMEND THIS MEDICATION TO ANYONE. PLEASE BE SAFE TAKING THIS MEDICATION.”

1 / 10
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KJF · Taken for 1 to 6 months · September 19, 2021

Wegovy (semaglutide) for Obesity: “I am currently on my 9th injection today, being my 8th full week being on Wegovy. I have lost a total of 40 pounds so far. Appetite is definitely curbed. Sunday’s when I take the injection and it makes me tired. A lot of gas and the occasional runs, but the weight loss is worth the side effects.”

9 / 10
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Mac · October 18, 2020

Ozempic (semaglutide) for Diabetes, Type 2: “Ozempic has caused me so much constipation !!! I know a side effect is diarrhea but it does the complete OPPOSITE for me . A day or two after I take my injection I have no bowel movements at all !! Every week I am forced to take a laxative . It has caused so many problems for me . Anyone else experienced severe constipation . So frustrated”

1 / 10
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Concerned · Taken for 1 to 6 months · February 1, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “I started Ozempic in late December at .25 injection. I also take 500mg metformin per day. Soon after I started Ozempic I had decreased apetitite and my sugars improved, but I had reflux, gas, bloating, nausea and diarrhea. After 4 weeks I started .50. 2 weeks in I have bouts of painful constipation then diarrhea, nausea, bloating, gas, reflux and cramping. I've almost vomited a few times. When I eat it feels like the food just sits and sits, barely moving through my gut. My doctor wants me to stick with it, saying that these side effects usually improve, but It's been pretty miserable. I'm thinking I'm going to stop taking it. While Ozempic has been effective in regulating my sugars and losing weight, I don't think it's worth the suffering that I've been enduring on this medication. I understand that studies showed it causing thyroid cancer in mice, but no one knows if it causes thyroid cancer in humans. I don't want to be the guinea pig the drug makers use to find out it does.”

5 / 10
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Anon · Taken for 1 to 6 months · May 19, 2020

Ozempic (semaglutide) for Diabetes, Type 2: “I was terrified to take this after reading some of the reviews online, but I have to say I am so happy I started this drug. I've followed others suggestions about injecting the drug into my upper thigh and not my abdomen. I was on a .25 dose for 4 weeks then moved to .5 and that's what I currently take. My appetite has decreased SIGNIFICANTLY. I was addicted to eating junk foods, and I simply cannot eat them anymore, my stomach cannot handle them. I get full after eating one proper sized meal, and it keeps me going for most of the day, only having a snack like 1 apple in the evening. Side effects were mild for me, had some constipation but I started taking fiber supplements to help with that. I have been on the medication for 7 weeks now and I'm down 10lbs and I feel great. Make sure your doctor gets you to increase the dose slowly, inject into your thigh and be ready to make better dietary choices when starting this drug. I truly believe it saved me from morbid obesity.”

10 / 10
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Jarin · Taken for 1 to 6 months · August 30, 2020

Rybelsus (semaglutide) for Diabetes, Type 2: “This med Rybelsus is awesome. It has helped me bring my A1C down to 5.1 from a high of 9.7. I first started with the 3mg and am now on the 14mg. Been on this med since March and while I did experience some nausea and mild upset stomach it went away after about a week. It has also helped me lose 50lbs as well. I also take with metformin. I should be the poster child for this drug...even though I'm 50.”

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Saucy · December 3, 2020

Ozempic (semaglutide) for Diabetes, Type 2: “Been on Ozempic since mid April 2020. All side effects listed with the worst being chronic diarrhea. Nausea has been significant, but has settled to occasionally. Trying to follow a more plant based diet I have lost today an official 60 pounds. I find the less meat I eat, the more energy I have, the better my blood sugars are as well. I am 53, so weight loss isn't impossible for us older ladies...”

7 / 10
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Cheryl · Taken for less than 1 month · January 30, 2022

Ozempic (semaglutide) for Cardiovascular Risk Reduction: “I did lots of research before starting Ozempic, so was aware of potential (hideous) side effects. I started a week ago on a starting dose on .25. (Had my second .25 dose this morning). Super super super happy!!! Based on research, I have opted to inject in my upper leg rather than my tummy. I don’t know if it’s based on the injection location, or if I’m just lucky, but I have had ZERO side effects. No nausea. No dizziness. Nothing. I am eating three sensible, small, low fat meals a day, with (perhaps) a small amount of fruit as a snack, and walk my dog regularly. I am down 1kg (2.2 pounds) over the week, and am super confident that I will be able to continue on Ozempic until I get down to my goal weight (20kg/44 pound to go). Although my doctor said he will increase my Ozempic to .5 then 1mg over the next 2 months, I am going to say no, and stay on .25 for as long as that works for me. (Why increase if the current dose is working!). I am 55. Cost in Australia = $132 per script.”

10 / 10
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More FAQ

jamison42 · Taken for 1 to 6 months · June 2, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “I have been on 0.5 Ozempic for 2 months now. The nausea is no better. I vomit almost every day. Driving down the road and I begin to vomit. Almost caused me to wreck my car twice now. I've lost 30 pounds and feel terrible. My stomach hurts all the time and now my back. I do not urinate much at all even though I've increased water. Calling today and going off it. Losing weight is great, but not at the cost of feeling horrible every day.”

5 / 10
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Kmac · Taken for 1 to 6 months · January 10, 2022

Wegovy (semaglutide) for Obesity: “First of all, this does work. I lost over ten pounds in 6 weeks. The weight just fell off. Second of all, this was the worst experience I have ever had with a prescribed medication. Well, I started at the lowest dose and took that for 4 weeks before moving to the next dose which I believe was 0.5 mg. The maintenance dose is 2.4 mg I believe. How anyone makes it to the 2.4 mg is beyond me. I made it to the second dose of 0.5 mg before I threw in the towel. This stuff is WICKED. I spent 6 weeks of my life with an upset stomach, the absolute worst reflux and heartburn I have ever had, and constant nausea. I had to literally force myself to eat. Would not recommend. The side effects and the price is not worth it. Easy to lose weight when you are starving yourself and feel too sick to eat. Once I stopped it took a few days to feel better and the weight came back lightening quick plus a few. Not worth the misery in my opinion.”

1 / 10
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Sane One · March 13, 2020

Ozempic (semaglutide) for Diabetes, Type 2: “After reading this, that junk in the fridge will go in the garbage. Do NOT put yourselves through this for weight loss and even diabetes. I mean seriously, which is worse? Pancreatitis? Thyroid cancer? Horrible gastro conditions? Injecting ourselves with this lizard juice can't be good for us. And, it’s beyond expensive to say the least. Pharmaceutical companies should be ashamed of themselves but that’s nothing new. This is totally off the charts. Just say no to drugs these drugs. Please be fair and unbiased and publish this comment, if you’re fair and unbiased!”

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Wegovy in MA · Taken for 1 to 6 months · February 8, 2022

Wegovy (semaglutide) for Obesity: “I'm in my second week of the 2.4mg dose of Wegovy. A lot of folks who posted mentioned cramps and nausea. I would usually experience this the first day and second day of injections early on but not so much now in the 2.4gm dose. The cure for the nausea that worked best for me was a couple bouillon cubes. Did the trick every time. Ate high protein and low carbs. Increased salads which are a key component of doing well with Wegovy and a low carb/high protein diet. I had gastric bypass in 2011 and lost quite a bit of weight which I kept off for a while, but gained almost all of it back through Covid and began Wegovy in October, 2021. As of today I have lost 67 lbs which is absolutely amazing. I am rehabbing for a knee replacement and this has been the absolute missing piece. This has removed all cravings of food, alcohol and most other things. My dosing day is Tuesday mornings and I can really tell on Monday afternoon/night as I start to get those cravings! Make good choices!”

10 / 10
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Anne · December 28, 2020

Rybelsus (semaglutide) for Diabetes, Type 2: “I started taking Rybelsus at the beginning of August for weight loss. The biggest con for me is that it causes constipation and then usually diarrhea when I finally do go to the restroom. I have only had issues with nausea when I try to eat past the point of being comfortable. It is also important to try to eat something within an hour of taking the medication. When I first started on the medicine, I could only eat a few bites of food and then would feel extremely full and bloated and would have to stop. Now, It is 4 full months later and I am on the 14mg and I can continue to eat beyond a few bites without feeling miserable, but I try to stop as soon as I am full. I have, so far, lost 30 lbs with no exercise and have gone from a size 12/14 to a size 6/8. Diabetes does run in my family, so I am hoping continued use of this drug may help prevent the development of diabetes in the future.”

10 / 10
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Will · Taken for 1 to 6 months · February 7, 2021

Ozempic (semaglutide) for Diabetes, Type 2: “Did the first 4 weeks o Ozempic @ .25 had mild stomach issues. Nausea was come and go really not consistent. Helped control my eating. Dr said if you over eat or eat like you used to you will throw up. There is no place for the over eating but up. Didn't over eat didn't have much issue. Took stool softener to keep things moving. At the .5 dose ate less but less side effects than my first dose. Glad I have started the med it works.”

10 / 10
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Momo · Taken for 1 to 2 years · April 30, 2020

Ozempic (semaglutide) for Diabetes, Type 2: “I have been taking Ozempic for 16 months and have lost 80Lbs! I started at .25 and have moved up to 1. At first I was terribly sick but I took my time to adjust bit by bit while the dose was slowly raised and now I don't feel sick at all from it now! If you can hold on and push through ( the push was hard, REALLY sick some days) it does get better. It has saved my life”

10 / 10
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LCMel · Taken for 1 to 6 months · March 18, 2022

Wegovy (semaglutide) for Obesity: “Wegovy has absolutely curbed my appetite at the .25 dose, I definitely do not feel nearly as hungry as I used to. I will eat maybe 1/3 to 1/2 of what used to be a normal portion for me and get signals to stop. It has not made me sick at all unlike other reviews. I think it's a real godsend for me with COVID and menopausal weight gain.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.