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Generic name: levetiracetam (oral/injection) [ LEE-ve-tye-RA-se-tam ]
Brand names: Keppra, Keppra XR
Drug class: Pyrrolidine anticonvulsants

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jun 28, 2024.

What is Keppra?

Keppra is an anti-epileptic drug, also called an anticonvulsant.

Keppra is a prescription medicine used to treat certain types of seizures in people with epilepsy, including partial onset seizures, myoclonic seizures, and tonic-clonic seizures.

When used for partial onset seizures:

Keppra is also used with other seizure medications to treat tonic-clonic seizures in people who are at least 6 years old, and myoclonic seizures in people at least 12 years old.

Keppra injection is used only as an alternative for patients when oral use is temporarily not possible.


Do not stop using Keppra without first talking to your doctor, even if you feel fine. You may have increased seizures if you stop using this medicine suddenly. You may need to use less and less before you stop the medication completely.

Some people have thoughts about suicide when first taking this medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

Wear a medical alert tag or carry an ID card stating that you take Keppra. Any medical care provider who treats you should know that you take seizure medication.

Keppra may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Do not start or stop taking levetiracetam during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both the mother and the baby. Seizure control is very important during pregnancy and the benefits of preventing seizures may outweigh any risks posed by using this medicine.

Before taking this medicine

You should not use Keppra if you are allergic to levetiracetam.

To make sure Keppra is safe for you, tell your doctor if you have ever had:

Do not give this medicine to a child without medical advice. Different brands of levetiracetam are for use only in children of certain ages.

Some people have thoughts about suicide while taking Keppra. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor if you become pregnant. Your dose needs may be different during pregnancy.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of levetiracetam on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I take Keppra?

Take Keppra exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Keppra oral is taken by mouth at the same time each day, with or without food.

Keppra injection is given in a vein if you are unable to take the medicine by mouth.

Your dose needs may change if you switch to a different brand, strength, or form of levetiracetam. A child's dose needs may change if the child gains or loses weight. Avoid medication errors by using only the brand, form, and strength your doctor prescribes.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Swallow the extended-release tablet whole and do not crush, chew, or break it.

Your kidney function may need to be tested.

Use all seizure medications as directed. Do not change your dose or stop using a medicine without your doctor's advice.

Seizures may increase if you stop using Keppra suddenly.. Ask your doctor before stopping the medicine.

Wear a medical alert tag or carry an ID card to let others know you have seizures.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, agitation, aggression, shallow breathing, weakness, or fainting.

What should I avoid while taking Keppra?

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Keppra side effects

Get emergency medical help if you have signs of an allergic reaction to Keppra (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel agitated, hostile, irritable, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

Common Keppra side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Keppra?

Other drugs may interact with levetiracetam, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Popular FAQ

Briviact (brivaracetam) and Keppra (levetiracetam) are anticonvulsant medicines that target the synaptic vesicle protein 2A (SV2A) in the brain. The newer agent Briviact is noted to be more selective and has a higher affinity for this receptor than Keppra. Continue reading

Aptiom (eslicarbazepine) is a once-daily oral seizure medicine (anticonvulsant) used alone or with other medicines to treat focal seizures (formerly called partial seizures). Keppra (levetiracetam) is an oral seizure medicine used to treat focal seizures, but is additionally approved to treat myoclonic seizures and tonic-clonic seizures. It is usually given twice a day. Both prescription treatments are used to treat adults and children of various ages with epilepsy. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Keppra only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.