Comparing Chlorzoxazone vs Diclofenac

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Chlorzoxazone

Diclofenac

Prescription only

Prescribed for Muscle Spasm. Chlorzoxazone may also be used for purposes not listed in this medication guide.

Prescription only

Diclofenac treats osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis by relieving pain, and inflammation. Ophthalmic forms reduce post-surgical eye swelling, pain, and light... View more

More about Chlorzoxazone

More about Diclofenac

Ratings & Reviews

Chlorzoxazone has an average rating of 6.7 out of 10 from a total of 64 ratings on Drugs.com. 58% of reviewers reported a positive effect, while 27% reported a negative effect.

Diclofenac has an average rating of 7.3 out of 10 from a total of 702 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 64 reviews

View all 702 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Drowsiness (14.1%)
Dizziness (6.3%)
Liver damage (6.3%)
Nausea (6.3%)
Headaches (4.7%)
Lightheadedness (4.7%)

View all Chlorzoxazone side effects

Upset stomach (4.8%)
Diarrhea (3.3%)
Nausea (3.3%)
Dizziness (2.8%)
Stomach pain (2.1%)
Drowsiness (2.0%)
Headaches (1.7%)

View all Diclofenac side effects

Drug Class

Skeletal muscle relaxants

Nonsteroidal anti-inflammatory drugs

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	10 tablet
Strength	500 mg
Per unit^*	$0.69
Cost^*	$6.91

View all Chlorzoxazone prices

Quantity	10 delayed release tablet
Strength	sodium 75 mg
Per unit^*	$0.69
Cost^*	$6.91

View all Diclofenac prices

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Dosage Forms

Oral tablet

Oral capsule
Oral delayed release tablet
Oral powder for reconstitution
Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

N/A

1.8 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category N Not classified

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Drug Interactions

A total of 370 drugs are known to interact with Chlorzoxazone:

36 major drug interactions (165 brand and generic names)
333 moderate drug interactions (1362 brand and generic names)
1 minor drug interactions (2 brand and generic names)

A total of 453 drugs are known to interact with Diclofenac:

100 major drug interactions (424 brand and generic names)
335 moderate drug interactions (1316 brand and generic names)
18 minor drug interactions (176 brand and generic names)

Alcohol/Food/Lifestyle Interactions

You should avoid or limit the use of alcohol while being treated with chlorzoxazone. Alcohol can... View more

Ask your doctor before using diclofenac together with alcohol. Do not drink alcohol while taking... View more

Disease Interactions

Hepatotoxicity

First Approval Date

August 15, 1958

July 28, 1988

WADA Class View classifications

N/A

More Information

Patient Resources

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Chlorzoxazone vs Diclofenac

See also:

Flexeril

Valium

Botox

Robaxin

Zanaflex

Soma

Diazepam

Methocarbamol

Baclofen

Tizanidine

Further information