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Chlorzoxazone Disease Interactions

There is 1 disease interaction with chlorzoxazone.


Chlorzoxazone (applies to chlorzoxazone) hepatotoxicity

Major Potential Hazard, Low plausibility. Applicable conditions: Liver Disease

The use of chlorzoxazone has been associated with rare cases of serious, idiosyncratic hepatocellular toxicity. Therapy with chlorzoxazone should be administered cautiously in patients with preexisting liver disease. All patients receiving chlorzoxazone should be instructed to immediately report any signs and symptoms of hepatic injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine and jaundice, and to discontinue the drug promptly should they occur. Chlorzoxazone therapy should also be withdrawn if abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase, bilirubin) develop.


  1. (2001) "Product Information. Parafon Forte (chlorzoxazone)." Ortho McNeil Pharmaceutical

Chlorzoxazone drug interactions

There are 363 drug interactions with chlorzoxazone.

Chlorzoxazone alcohol/food interactions

There is 1 alcohol/food interaction with chlorzoxazone.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.