Chlorzoxazone Disease Interactions
There is 1 disease interaction with chlorzoxazone.
Chlorzoxazone (applies to chlorzoxazone) hepatotoxicity
Major Potential Hazard, Low plausibility. Applicable conditions: Liver Disease
The use of chlorzoxazone has been associated with rare cases of serious, idiosyncratic hepatocellular toxicity. Therapy with chlorzoxazone should be administered cautiously in patients with preexisting liver disease. All patients receiving chlorzoxazone should be instructed to immediately report any signs and symptoms of hepatic injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine and jaundice, and to discontinue the drug promptly should they occur. Chlorzoxazone therapy should also be withdrawn if abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase, bilirubin) develop.
- "Product Information. Parafon Forte (chlorzoxazone)." Ortho McNeil Pharmaceutical (2001):
Chlorzoxazone drug interactions
There are 312 drug interactions with chlorzoxazone.
Chlorzoxazone alcohol/food interactions
There is 1 alcohol/food interaction with chlorzoxazone.
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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