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Chlorzoxazone Dosage

Medically reviewed by Last updated on Oct 19, 2022.

Applies to the following strengths: 250 mg; 500 mg; 750 mg; 375 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Muscle Spasm

Initial dose: 250 to 500 mg orally 3 to 4 times a day

  • If inadequate response, may increase to 750 mg orally 3 or 4 times a day

  • The dose should be reduced as improvement occurs.

Use: As an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

Renal Dose Adjustments

No adjustments recommended

Liver Dose Adjustments

Use with caution; discontinue immediately if signs or symptoms of hepatotoxicity or abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase and bilirubin) develop



  • Known intolerance to the drug

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

  • Take orally

  • Monitor for hepatotoxicity including liver function tests as warranted.

Patient advice:
  • Patients should be instructed to immediately report signs or symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice.
  • Patients should be advised to speak with their health care provider regarding concomitant use of alcohol or other central nervous system depressants as these may have an additive effect.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.