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Chlorzoxazone Dosage

Medically reviewed on December 5, 2017.

Applies to the following strengths: 250 mg; 500 mg; 375 mg; 750 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Muscle Spasm

250 to 750 mg orally 3 to 4 times a day.

The dosage may be reduced as the condition of the patient improves.

Usual Pediatric Dose for Muscle Spasm

125 to 500 mg orally 3 to 4 times a day.

Alternative dosing: 20 mg/kg/day in divided doses 3 to 4 times a day.

Renal Dose Adjustments

No adjustments recommended

Liver Dose Adjustments

Chlorzoxazone is contraindicated in patients with liver dysfunction.


If any signs or symptoms suggestive of liver dysfunction are observed, the drug should be discontinued.

Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving chlorzoxazone. Patients should be instructed to report early signs and/or symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice.


Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.