Zofran Alternatives Compared
| Zofran (ondansetron) | Ondansetron | Promethazine |
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| Zofran (ondansetron) | Ondansetron | Promethazine |
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Prescription only
Zofran is used to prevent nausea and vomiting caused by cancer chemotherapy, radiotherapy, or surgery. It is approved for use in adults and children over the age of 4 and is available as tablets... View more |
Prescription only
Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Prescribed for Nausea/Vomiting, Gastroenteritis, Alcohol Use Disorder... View more |
Prescription only
Promethazine is used to treat and prevent allergies (rhinitis, conjunctivitis, skin reactions), for anaphylaxis support, for motion sickness/nausea, as a sedative, and for dermatological conditions... View more |
Related suggestions Nausea/Vomiting
Popular comparisons
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| More about Zofran (ondansetron) | More about Ondansetron | More about Promethazine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Zofran has an average rating of 8.0 out of 10 from a total of 273 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 15% reported a negative effect. |
Ondansetron has an average rating of 7.8 out of 10 from a total of 503 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 17% reported a negative effect. |
Promethazine has an average rating of 7.2 out of 10 from a total of 398 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Zofran side effects |
View all Ondansetron side effects |
View all Promethazine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Ondansetron prices |
View all Promethazine prices |
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| Dosage Forms | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
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N/A |
N/A |
Adgan, Anergan 50, Antinaus 50, Phenadoz, Promethegan | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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4 hours |
4 hours |
16 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 364 drugs are known to interact with Zofran:
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A total of 364 drugs are known to interact with Ondansetron:
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A total of 692 drugs are known to interact with Promethazine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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December 31, 1992 |
January 04, 1991 |
March 29, 1951 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.