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Ondansetron User Reviews & Ratings

Ondansetron has an average rating of 7.8 out of 10 from a total of 476 reviews on Drugs.com. 73% of reviewers reported a positive experience, while 19% reported a negative experience.

Reviews for Ondansetron

  • zofra...
  • Taken for 2 to 5 years
  • December 18, 2019

Zofran (ondansetron) for Nausea/Vomiting "I have been taking this medication at least once a week for about four years now. I have terrible stomach issues now that I no longer have my gallbladder that cause stomach pain, nausea and no appetite, as well as anxiety that manifests as nausea and stomach pain. I also have a HUGE fear of vomiting. This pill has always worked and kept me from vomiting, but on occasion the nausea sticks around but it’s nothing too terrible. I don’t know what I would do without this medication. It helps me live a normal life. I take 4 mg every 4-6 hours as needed, if it’s a rough day I’ll take 8 mg every 6-8 hours. The only downfall is the side effect of constipation, but as someone who is terrified of vomiting, I’ll take the constipation over vomiting any day."

9 / 10
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  • Steve
  • Taken for 2 to 5 years
  • October 28, 2019

Zofran (ondansetron) for Nausea/Vomiting "I take oxycodone for chronic persistent back pain because of spinal stenosis. As a result I frequently have nausea and vomiting, roughly 4-5x/week. My pain management doctor always prescribes Zofran which doesn’t help in the slightest. I tell him this but he keeps prescribing it none the less. He says it is safe and doesn’t make you sleepy. I say if it doesn’t work what good is it. My GI doctor gave me phenergan which does help but he tells me to go back to the pain guy to get more. I go back, tell him yet he just gives me more Zofran. DON'T YOU JUST LOVE PHYSICIANS WHO LISTEN TO THEIR PATIENTS(sarcasm)."

2 / 10
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  • Pukin...
  • Taken for 5 to 10 years
  • March 22, 2018

Zofran (ondansetron) for Gastroenteritis "God bless the manufacturers of Zofran! I am phobic about vomiting - panic attacks just thinking about it. That little miracle dissolves on my tongue and takes away the nausea and fear. It has saved me trips to the ER for gastric issues. I never want to be without it."

10 / 10
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129 Report

Frequently asked questions

  • PJ Sh...
  • June 21, 2019

Zofran (ondansetron) for Gastroenteritis "Salute to the inventor of this medicine Ondansetron . I have IBS-D and with severe flatulance discomfort and suffocating feeling. After taking the mouth dissolving tablet it acts like miracle. At first all the entrapped gas in abdomen comes out in the form of belching and burping and thereafter the normalcy comes to the body and mind. All other medicines have not worked . This is great. "

10 / 10
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  • Pickled
  • Taken for 1 to 2 years
  • April 20, 2021

Zofran ODT (ondansetron) for Nausea/Vomiting "This medication makes me more nauseous than before taking it. After 3 surgeries and multiple nausea filled days due to a chronic health condition, I’ve concluded that this drug makes things worse for me. I kept hoping it was all in my head, but other anti nausea meds (and even peppermint) work almost immediately, at least to a certain extent. Whereas this always makes me 10x worse to the point of vomiting. It also gives me really bad headaches and I don’t ever get headaches in general. It’s the only medication that gives me this side effect. So I think this either works very well for people, or makes it worse. I’m wondering if it has to do with brain chemistry since it’s a serotonin blocker? I’m severely ADHD with mild OCD and depression. Perhaps certain brain wiring just doesn’t benefit. I’d love more research to be done on this since it’s the standard anti nausea treatment given in hospitals."

1 / 10
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Are you taking this medicine?

  • camille
  • August 7, 2014

Zofran (ondansetron) for Nausea/Vomiting "I have generalized anxiety disorder and suffer from emetophobia. The anxiety causes stomach upset and the fear of throwing up increases the anxiety in a vicious cycle. My psychiatrist prescribed Zofran while I was trying out SSRI's to help me get through the first few weeks of side effects. I am now on Celexa with a lot less anxiety and only take Zofran as needed! It works great it just makes me feel sleepy. Haven't run into any constipation yet."

10 / 10
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147 Report
  • Mel
  • Taken for less than 1 month
  • January 5, 2020

Zofran (ondansetron) for Nausea/Vomiting "I've taken this medication other various occasions and honestly it's a life saver. Today I woke up with a stomach bug. I got out of bed and drank a glass of water and not even five minutes later I was bent over the toilet. I laid down and maybe half an hour later again. Within two hours I had taken six horrible, dry heaving, painful and exhausting visits to the bathroom. Finally rushed to the Dr, where it happened one more time before being seen. She quickly gave me one of these and I haven't thrown up or felt nauseous since. I've been able to keep down liquids and solids with ease. I see this medication as a great tool to help me get better faster than expected!"

10 / 10
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75 Report
  • Dolphin
  • Taken for less than 1 month
  • June 5, 2020

Zofran (ondansetron) for Nausea/Vomiting "I have Acute Gastritis and this medicine makes me feel worse. Too many side effects associated with it. I feel more pain in my stomach, light headed, dizzy and just overall bad. I was starting to feel better before I took this medicine and now I have to wait for it run its course."

2 / 10
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65 Report
  • Mandy...
  • Taken for less than 1 month
  • September 26, 2014

Zofran (ondansetron) for Nausea/Vomiting "I had the Norovirus last year and took Zofran and it worked very well. The pills are small and dissolve easily on your tongue so you don't have to drink water and risk throwing up the medicine. If possible, I think it would be great to offer this medication over the counter."

10 / 10
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114 Report
  • Tired...
  • Taken for less than 1 month
  • June 22, 2019

Zofran (ondansetron) for Gastroenteritis "Gastroenteritis is horrible. I started feeling sick and gassy on the first day. On the second day I thought I was dying. The pain and burning was so bad it made my chest hurt and I thought I was having a heart attack or anxiety attack. Went to the doctor, was prescribed Zofran, almost took the sickness away completely! Still some burning in the lower abdomen, but finally some relief!!!"

10 / 10
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  • Anonymous
  • Taken for less than 1 month
  • April 20, 2013

Zofran ODT (ondansetron) for Nausea/Vomiting "I've been taking ondansetron ODT 8mg tabs for about 2 days due to nausea caused by a kidney infection. When I take the tablet it doesn't help and makes me more nauseous than I was before. I just took it a half hour ago to be sure, and I immediately became more nauseous. So I'm pretty sure it just doesn't work for me, and I'm wondering if anyone else has this problem?"

2 / 10
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117 Report
  • Hggirl
  • April 22, 2021

Zofran (ondansetron) for Nausea/Vomiting "I have Hyperemesis gravidarum (HG) and have been miserable. Zofran is keeping me out of the ER right now. At first I noticed it made me a little dizzy and it still makes me feel just a little weird within the first hour but it’s extremely tolerable. The constipation is super annoying but talk to your doctor about it if that’s an issue and you can probably take something to help that. It stops me from throwing up but I am still definitely nauseous. Brings it from like a 10 to a 5 or 6 maybe but I can EAT now. That is huge. I am eating small meals when I haven’t had a meal in weeks. I’ve been barely eating and drinking. I am completely dependent on zofran to be any type of functional right now. It makes me a little tired but also gives me more energy to not just stay in bed all day because it makes me feel better. Highly recommend, just watch out for the side effects I mentioned. Nothing to be scared of extremely tolerable for me :)"

8 / 10
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  • Dano
  • Taken for 5 to 10 years
  • December 24, 2020

Zofran (ondansetron) for Gastroenteritis "I have been on Zofran for 8 years and it has been a lifesaver. I wake up nauseous every single day and the Zofran works within a half hour and I rarely need a repeat dose. I don't know what I would do without it!"

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  • Vhano
  • Taken for less than 1 month
  • December 23, 2019

Zofran (ondansetron) for Nausea/Vomiting "Day 1 of what the docs think is the flu, first time puking in a long time. Couldn't hold down water or pepto. Was so nauseous I was having dreams that were making it worse. Zofran has kicked my nausea and now I can eat and drink again and therefore take ibuprofen and my flu meds. Holy cheese batman"

10 / 10
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49 Report
  • KPP
  • Taken for 10 years or more
  • January 4, 2020

Zofran (ondansetron) for Nausea/Vomiting "I’ve had a fear of vomiting for years (25+). Found out about this MED when my best friend has hyperemesis while pregnant and it helped her to stop vomiting. I asked my dr if I could get it because I had such horrible anxiety about throwing up. I take zofran 4-8mg when I have bad nausea and anxiety and it seems to help me. I did throw up once after taking it but I think It was because I had worked myself up so much!"

9 / 10
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45 Report
  • Anonymous
  • September 15, 2011

Zofran (ondansetron) for Nausea/Vomiting "I suffer from both severe emetophobia (fear of vomiting) AND a panic disorder which causes nausea and gastric upset. I spent many years trapped in a horrible cycle of panicking any time I felt the slightest twinge of nausea, which in turn, induced intense stomach upset, sometimes to the point of heaving. I've tried other anti-nausea medication in the past (Phenergran, Compazine), with so-so results, and the annoying side effect of extreme drowsiness. Zofran has been a real lifesaver for me. Within minutes of taking a pill, my nausea subsides. The only side effect I've experienced has been constipation, but I'll take that over vomiting any day! "

9 / 10
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98 Report
  • preggo
  • Taken for less than 1 month
  • March 2, 2015

Zofran (ondansetron) for Nausea/Vomiting "I'm taking this for morning sickness, I feel like it has given me my life back. I lost over 6 lbs in 5 days due to nausea and vomiting, and was too sick to do anything for my toddler, myself, or my home. I can tell when it's starting to wear off (at about 6.5-7 hr.) because the nausea comes right back. I'll take being backed up and a little drowsy as a side effect... it allows me to eat and keep things down and be present in my family's life. Never thought I'd be so happy to take a medication, but I'm SO thankful for Zofran."

10 / 10
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72 Report
  • Xtiff...
  • March 9, 2015

Zofran (ondansetron) for Nausea/Vomiting "The only medication that really does the trick. I have been prescribed to it twice now due to a severe stomach virus and it gave me relief after 20 minutes! Didn't throw up any more afterwards and helped me sleep after a very restless night. Love it!"

10 / 10
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70 Report
  • Troy
  • Taken for less than 1 month
  • August 29, 2019

Zofran (ondansetron) for Gastroenteritis "Had gastroenteritis, couldn't stop vomiting. Called doctors on call, they came out at 2am and gave me a shot of maxolon (which worked in the past). Was good for about an hour and then it started again, every half hour until I felt like I was going to pass out. Went to the hospital, they gave me a Zofran wafer and I stopped throwing up within 10 minutes. Felt terrible from dehydration but the Zofran wafer stopped the vomiting in its tracks. I now keep Zofran wafers at home, let myself throw up 2-3 times when I get a stomach bug and then pop a Zofran wafer to stop it. Best thing ever."

10 / 10
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  • hhgvi...
  • Taken for less than 1 month
  • October 14, 2013

Zofran (ondansetron) for Gastroenteritis "This is my miracle medicine. Best medicine I have ever taken in my life. Works for me in 1-2 minutes. Have nausea from acid reflux and feel instantly better. A little sleepy but it doesn't put me in a deep slumber. Love Zofran."

10 / 10
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69 Report
  • Anonymous
  • August 10, 2011

Zofran (ondansetron) for Gastroenteritis "I took my 16 year old daughter into the ER after stomach cramps and throwing up all day long. She was at the point she was so thirsty she would put water in her mouth and then spit it out because even a little water and she would throw up. Once they gave her this medication she was able to drink a full glass of water within minutes and walked out of the ER wanting Mexican (which she did not get). What a difference it made?"

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  • Bethy...
  • Taken for 6 months to 1 year
  • June 27, 2016

Zofran (ondansetron) for Nausea/Vomiting "I have crohns disease, emetephobia & i also take quite a few pain meds for chronic pain all of which make me extremely nauseous so i suffer nausea allooot! Ondansetron is a life safer for me i take 4 mg every 8-12hrs on a good day some days i take 8mg if its really bad! Ive been taking it daily for nearly 6 months and it is still as affective as the first time i took it! I live in the uk so am fortunate that i dont have too pay eye watering prices. Id reccomend too anybody its brilliant"

10 / 10
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53 Report
  • Anonymous
  • December 13, 2011

Zofran (ondansetron) for Gastroenteritis "I have used Zofran on two different occasions. Went to the Dr for assistance after a week of vomiting because I was so miserable and weak. Felt so much better within 30 minutes I started eating the first thing I saw. Second time I used it to bypass the stomach flu that everyone was catching. I took it within 2 hours of symptoms; I fell asleep shaking, heart racing, with a fever and cold sweat, clutching a bucket to throw up in. Woke up 6 hours later feeling absolutely fine, just a little hungry."

10 / 10
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73 Report
  • qh3rdb
  • Taken for less than 1 month
  • May 21, 2015

Zofran (ondansetron) for Nausea/Vomiting "I was extremely hungover and was vomiting for about 14 hours non-stop before being prescribed Zofran. I know it seems silly to get medication for a hangover, but I was becoming dangerously dehydrated from the binge drinking and heavy vomiting, as I was unable to keep even a sip of water down. Not even ten minutes after taking the medicine (dissolvable pills), I already felt significant relief from the nausea, and therefore the vomiting as well. A bit expensive, but completely worth it."

10 / 10
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57 Report
  • panic...
  • Taken for less than 1 month
  • February 8, 2015

Zofran (ondansetron) for Nausea/Vomiting "Last night I had severe diarhhea and stomach pain and dizziness, maybe I was dehydrated from the stomach bug so I went to the ER and they said they were going to give me Zofran, which I have a phobia of trying new pills but my stomach hurt so bad, I told the nurse I'd break it in half till I seen how small it was, and she said just let it dissolve on your tongue so I did and it had a strawberry flavor which I told her wow this taste good, and within about 5 minutes my nausea had gotten so much better, even relaxed me a bit, I'm telling you folks if you have the stomach bug or stomach aches, give this a shot I had no side effects at all, maybe a little sleepiness but like others I'll take that over the stomach pain, thanks Zofran."

10 / 10
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56 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.