Ondansetron and Nausea: What Users Say

• zof...
• Taken for 2 to 5 years
• December 18, 2019

Ondansetron for Nausea/Vomiting "I have been taking this medication at least once a week for about four years now. I have terrible stomach issues now that I no longer have my gallbladder that cause stomach pain, nausea and no appetite, as well as anxiety that manifests as nausea and stomach pain. I also have a HUGE fear of vomiting. This pill has always worked and kept me from vomiting, but on occasion the nausea sticks around but it’s nothing too terrible. I don’t know what I would do without this medication. It helps me live a normal life. I take 4 mg every 4-6 hours as needed, if it’s a rough day I’ll take 8 mg every 6-8 hours. The only downfall is the side effect of constipation, but as someone who is terrified of vomiting, I’ll take the constipation over vomiting any day."

• Ste...
• Taken for 2 to 5 years
• October 28, 2019

Ondansetron for Nausea/Vomiting "I take oxycodone for chronic persistent back pain because of spinal stenosis. As a result, I frequently have nausea and vomiting, roughly 4-5 times a week. My pain management doctor always prescribes Zofran which doesn’t help in the slightest. I tell him this, but he keeps prescribing it nonetheless. He says it is safe and doesn’t make you sleepy. I say if it doesn’t work, what good is it? My GI doctor gave me Phenergan, which does help, but he tells me to go back to the pain guy to get more. I go back, tell him, yet he just gives me more Zofran. DON'T YOU JUST LOVE PHYSICIANS WHO LISTEN TO THEIR PATIENTS (sarcasm)."

• Pic...
• Taken for 1 to 2 years
• April 20, 2021

Ondansetron for Nausea/Vomiting "This medication makes me more nauseous than before taking it. After 3 surgeries and multiple nausea-filled days due to a chronic health condition, I've concluded that this drug makes things worse for me. I kept hoping it was all in my head, but other anti-nausea meds (and even peppermint) work almost immediately, at least to a certain extent. Whereas this always makes me 10x worse to the point of vomiting. It also gives me really bad headaches, and I don't ever get headaches in general. It's the only medication that gives me this side effect. So I think this either works very well for people or makes it worse. I'm wondering if it has to do with brain chemistry since it's a serotonin blocker? I'm severely ADHD with mild OCD and depression. Perhaps certain brain wiring just doesn't benefit. I'd love more research to be done on this since it's the standard anti-nausea treatment given in hospitals."

• Anonymous
• Taken for less than 1 month
• April 20, 2013

Ondansetron for Nausea/Vomiting "I've been taking ondansetron ODT 8mg tablets for about 2 days due to nausea caused by a kidney infection. When I take the tablet, it doesn't help and makes me more nauseous than I was before. I just took it half an hour ago to be sure, and I immediately became more nauseous. So I'm pretty sure it just doesn't work for me, and I'm wondering if anyone else has this problem?"

• Vha...
• Taken for less than 1 month
• December 23, 2019

Ondansetron for Nausea/Vomiting "Day 1 of what the docs think is the flu, first time puking in a long time. Couldn't hold down water or Pepto. Was so nauseous I was having dreams that were making it worse. Zofran has kicked my nausea, and now I can eat and drink again and therefore take ibuprofen and my flu meds. Holy cheese, Batman."

• Bet...
• Taken for 6 months to 1 year
• June 27, 2016

Ondansetron for Nausea/Vomiting "I have Crohn's disease, emetophobia, and I also take quite a few pain meds for chronic pain, all of which make me extremely nauseous, so I suffer nausea a lot! Ondansetron is a lifesaver for me. I take 4 mg every 8-12 hours, and on a good day, some days I take 8 mg if it's really bad! I've been taking it daily for nearly 6 months, and it is still as effective as the first time I took it! I live in the UK, so I am fortunate that I don't have to pay eye-watering prices. I'd recommend it to anybody, it's brilliant."

• qh3...
• Taken for less than 1 month
• May 21, 2015

Ondansetron for Nausea/Vomiting "I was extremely hungover and was vomiting for about 14 hours non-stop before being prescribed Zofran. I know it seems silly to get medication for a hangover, but I was becoming dangerously dehydrated from binge drinking and heavy vomiting, as I was unable to keep even a sip of water down. Not even ten minutes after taking the medicine (dissolvable pills), I already felt significant relief from the nausea, and therefore the vomiting as well. A bit expensive, but completely worth it."

• Ita...
• Taken for less than 1 month
• December 9, 2016

Ondansetron for Nausea/Vomiting "I've had central vertigo for years, but the nausea and vomiting have increased lately. My gastroenterologist prescribed Zofran 4 mg once a day. It's a miracle! I can go out and shop without vomiting in the aisles of the grocery store. I have my life back."

• Ari...
• January 25, 2017

Ondansetron for Gastroenteritis "This is a miracle drug! So many times, Zofran came in for the save. Saved my spouse, I, and our 7 and 5-year-old a trip to the ER when the norovirus hit us. Took it after terrible dry heaves, and within 20 minutes, I was able to sleep. This medicine also helped after my C-section when I was nauseous. When my son had hand, foot, and mouth and was uncontrollably vomiting, the doctor gave him this medicine too, within an hour, he was eating fine! This was also great for my IBS symptoms when they hit hard. 10/10!"

• Dan...
• August 19, 2019

Ondansetron for Nausea/Vomiting "This is the best medicine for vomiting I have ever had. I was on IV antibiotics with a lot of side effects, especially nausea, and the antibiotics could not be changed. I literally could not hold down water. I had to be on them for 3 months, and Zofran (both IV and ODT) helped me immensely. I was able to drink and even eat a little with much less nausea. People have to remember no medication may make symptoms resolve completely every time, but this comes pretty close. When I took it for regular nausea from a virus or something, it worked like 100% nausea gone. For me, there were no side effects, and again people have to remember if you're sick, some of the symptoms may not be side effects. If you're vomiting repeatedly and are dehydrated, of course, you're going to have a headache. But everyone is different, so what works for one may not have the same effects for another. But I'm a health care worker, and whoever is given Zofran usually has relief, so give it a try if your doctor says it's okay! Good luck."

• Sic...
• March 21, 2016

Ondansetron for Nausea/Vomiting "Was very sick from antibiotics and large doses of Prednisone to help with the asthma. Couldn't hold any food down but did take enough water and Gatorade. Kept losing weight and had terrible abdominal cramps with the nausea. Finally saw another doctor after 11 days who prescribed the Zofran, and all nausea and cramps totally went away. Finally, I could start eating again! Zofran was a miracle med for me!"

• Dda...
• May 5, 2017

For Alcohol Use Disorder "In my chequered relationship with alcohol (35 yrs), I have found my way back to sobriety, crippled with nausea and vomiting many times. I have tried the usual suspects over the years. Medicines which increase motility (emptying of the stomach more quickly) right up to phenothiazines (used to relieve, amongst other things, seasickness and psychosis). Google anti-emetics. If you want to get sober, do it over a one-week to ten-day period with family support (probably more important than any drug). Ask your doctor for a serious anti-sickness drug, keep hydrated!!! Drink ginger tea! And rest. Good luck, my advice was sound for me. God bless, Dave. X"

• Anonymous
• Taken for less than 1 month
• November 1, 2015

Ondansetron for Gastroenteritis "Like one of the reviews above. I went into the ER with gastroenteritis symptoms. Could not keep down anything, including water, due to nausea and heavy vomiting of anything. Was given an injection of Zofran and a prescription for the generic ondansetron and felt less nauseous. Allows me to eat better and to sleep."

• Chr...
• Taken for less than 1 month
• April 5, 2016

Ondansetron for Nausea/Vomiting "I was taking Zofran for awful stomach upset with nausea because one of my other medicines I was on, I picked up at the pharmacy, was a generic new form of medication to treat pain. This new medicine made me very sick. Zofran helped out a lot, plus I could take it up to four times per day. However, I'm also on Lexapro for depression and panic attacks. One day, after 2 weeks on these meds, I had severe shaking happening to me, and I never felt this way before. Come to find out taking both the Zofran and Lexapro on the same day each day was a high risk of a drug interaction, very severe, and I was having the symptoms of a bad interaction. I need to change my Lexapro to another type of depression med. But, every depression med is bad with Zofran."

• Gro...
• Taken for less than 1 month
• April 23, 2018

Ondansetron for Gastroenteritis "I’ve been sick with the stomach flu since last night. Ate dinner, then a couple of hours later was in the bathroom throwing up with major diarrhea. Stayed on the toilet literally all night. It was one of those “one little move and you feel like you’re going to throw up” times. Well, once morning came the puking stopped, but I was still really nauseous with dry heaves. So I called my doctor to see if there was anything I could take, and they recommended Zofran. Wow, is this a miracle drug! My nausea was gone within 10-15 minutes of taking it, and I was even able to hold down a couple of popsicles and water with it, until about an hour and a half ago when I started feeling nauseous again (the meds were wearing off, so I took another one, and within 10 minutes my nausea was gone! I even ate another popsicle and downed a little juice glass of water and didn’t throw up! If this little white, grape-flavored pill isn’t magic, then I don’t know what is!"

• Anonymous
• October 10, 2012

Ondansetron for Nausea/Vomiting "I can't say enough about Zofran. I was curled in a fetal position in front of the bathroom, on the floor, in a cold sweat after vomiting for the last two hours. The last bout was dry heaving. Still, the nausea was crippling me. My wife gave me one pill, and within 30 minutes, the hell I was going through broke like an ocean tide receding. I keep Zofran in the medicine cabinet now, at all times."

• swi...
• Taken for 5 to 10 years
• September 13, 2020

Ondansetron for Nausea/Vomiting, Chemotherapy Induced "I went through a pure nightmare during chemo for my triple negative BC in 2015. Nausea is an understatement. My oncologist told me that I was the worst patient she ever had with nausea. This is a woman who was practicing in the '70s when they still treated with mercury. I cannot tell you how many nausea medications I was prescribed. Zofran was by far the BEST medication at relieving my symptoms. Five years later I still cannot 'handle' any kind of nausea. I have an 'emergency' prescription that I have with me 24/7. I only need it maybe twice a year, but it is still the magic bullet that relieves any nausea/vomiting I may have. I HIGHLY RECOMMEND THIS MEDICATION!!!"

• Wil...
• September 23, 2013

Ondansetron for Nausea/Vomiting "I suffer from chronic lower back pain due to scoliosis and arthritis (42 yrs old). I also suffer from irritable bowel syndrome. I take Zofran almost daily to deal with the miseries of both lower back pain and digestive issues. I still have regular bouts of vomiting, however, Zofran will stop the pain and nausea that would continue for days and land me in the hospital with an IV delivering morphine into my system to stop the cycle of vomiting, nausea, and severe pain. I love my Zofran! It makes life 'livable.'"

• Cat...
• Taken for less than 1 month
• February 22, 2021

Ondansetron for Nausea/Vomiting "Horrible drug for me. Actually makes me nauseous and throws up. Nothing tastes right on this medication. One dose had me throwing up and nauseous, not able to eat for a couple of days. One dose had me constipated for about 5 days before I was back to normal (with taking stool softeners Rx after surgery). May work for some, but for me, it’s a NO go."

• Mom...
• October 16, 2015

Ondansetron for Nausea/Vomiting "Ever since the 5th week of my pregnancy, my morning sickness was terrible. I lost weight and couldn't keep a thing down. I could hardly get out of bed. My doctor prescribed Zofran, and it's been a huge help. Doesn't always take away the nausea feeling, but no more vomiting! Definitely recommend it."

• pra...
• March 3, 2010

Ondansetron for Nausea/Vomiting, Radiation Induced "I have esophageal cancer, having radiation daily and chemo weekly. This medicine is so precise about keeping the nausea and vomiting down, I can tell exactly when a dose is due: 1 every 12 hours. I am thankful this medicine is there. The side effects are very bearable (unknown concerning liver). It is very expensive, but if you have a severe issue, the money is not your main concern. If you have cancer, there are agencies that can help with the drug cost. Try AM Cancer Soc. Maybe they can help guide you. Keep your spirits up and prayers in your daily life. Take care."

• Che...
• Taken for 1 to 6 months
• December 29, 2016

Ondansetron for Nausea/Vomiting "I used to take Requip for restless leg syndrome, and sometimes it made me so sick I would vomit. Other nights it would be fine. One day I decided to call my PCP for a script of Zofran or Phenergan to help subside the horrible, nasty vomiting and nausea effects of Requip, and they wrote me a script of 12 4 mg Zofran swallowable tablets. It helped almost immediately (not within a minute, but 10 minutes or less), and then I decided to stop my Requip medication because it just made me sick. My RLS went away with other meds that I take, and while I still take Zofran, I enjoy it for any spur-of-the-moment 'I'M GONNA BE SICK' kind of feeling, so I always carry it with me. At a hospital visit, they gave me a dissolvable one that tasted like berries. Good med."

• Anonymous
• March 16, 2008

Ondansetron for Nausea/Vomiting "The side effects from various drugs, particularly morphine, caused significant nausea. In fact, I'd have to rate the nausea as worse than the actual pain. Zofran worked like a charm, quite quickly, with little side effects (as far as I know). It certainly made my recent visit to the hospital much more comfortable!"

• Vom...
• June 25, 2016

Ondansetron for Gastroenteritis "Spent a week vomiting and with diarrhea. Couldn't keep anything down and was getting worse instead of better. I ended up driving to the ER with a vomit bag to my face, trying not to crap myself. When they gave me the Zofran, I felt better in 5 minutes and was able to eat a little plain chicken and rice with broth a couple of hours later. I didn't realize just how much nausea I had until the whole room suddenly stopped waving. Slept better than I have in a long time, and this morning I didn't throw up! Crackers and Gatorade for breakfast! Every 6 hours, and I love this little pill."

• Anonymous
• April 7, 2008

Ondansetron for Nausea/Vomiting "My mother was down to 78 lbs due to nausea. Phenergan had been the only drug her Dr. would prescribe. This continued for 3 months until someone told me about Zofran. I asked if we could please try it, it was amazing. I'm positive, if we hadn't asked about this drug, she would be dead from starvation due to nausea."