Ondansetron and Sleepy: What Users Say

• hhg...
• Taken for less than 1 month
• October 14, 2013

Ondansetron for Gastroenteritis "This is my miracle medicine. Best medicine I have ever taken in my life. Works for me in 1-2 minutes. Have nausea from acid reflux and feel instantly better. A little sleepy but it doesn't put me in a deep slumber. Love Zofran."

• OLo...
• Taken for 1 to 2 years
• May 3, 2014

Ondansetron for Nausea/Vomiting "This medication works wonders for me whenever I feel sick or nauseous. The flavored tablets that disintegrate under the tongue or in the mouth are very convenient and work really quickly to relieve nausea/vomiting. The only real side effect from it that I have noticed is a slight tired feeling. I'd much rather feel a little sleepy than sick to my stomach. I really recommend this medicine if your doctor also feels that it is right for you."

• asb...
• Taken for 6 months to 1 year
• August 22, 2014

Ondansetron for Nausea/Vomiting "I've had recurring nausea for over a year now. The bouts of nausea, dry heaving, and vomiting only bile would last for hours. Phenergan did nothing, but Zofran, within 5 min (usually), I'm cured. It does make you sleepy, but well worth a little tiredness. It is expensive without insurance."

• Zof...
• Taken for less than 1 month
• June 28, 2022

Ondansetron for Nausea/Vomiting "I am having severe digestive issues, and we are trying to figure out what it is. Gastritis? Gallbladder attack? (I do have a gallstone.) IBS? Ulcer? Just don’t know. I have horrible anxiety and stress when something is wrong with me. That probably adds to the nausea. I get nauseous, and it hurts like a gnawing pain. I can’t really eat, it’s miserable. Went to the ER twice, and they administered Zofran, let me tell you! It is a miracle drug! Painful nausea gone! I feel so much more calm, and the gas/bloating is gone. I didn’t experience any effects. Even if I get sleepy, it’s a welcomed side effect after feeling yucky for days! Give it a try!!"

• MsD...
• September 30, 2014

For Gastroenteritis "I have suffered with gastrointestinal/irritable bowel syndrome problems for 15 years. This medication is literally a 'miracle worker.' Anytime I have a flare-up that causes nausea/vomiting, I take one pill of this and I am fine just minutes later. I remember thanking my doctor over and over for finding this medication for me. I agree with others that it makes you a little sleepy (does not knock you out though), and also if you use it several days in a row (which hopefully you do not), it can and may cause constipation. I would recommend this to anyone with frequent and/or recurring GI/IBS episodes."

• Nic...
• Taken for less than 1 month
• October 3, 2018

Ondansetron for Nausea/Vomiting "At first, it worked for me when it was given to me at the hospital. It was then prescribed to me by my doctor for nausea and vomiting from gallstones. After a few hours of taking Zofran, I started to experience body tremors, and I still have residual nausea too. It also makes me feel very sleepy from it too. I think it has also caused me to be constipated since I haven't had a bowel movement in a few days. Not sure if I would recommend this to anyone. It does kind of work, but not well for me."

• Sza...
• November 28, 2011

For Nausea/Vomiting, Postoperative "I had surgery, and the postoperative narcotics made me very nauseous, and I had to throw up. A full dose (8 mg) of ondansetron helped but did not fully resolve the problem. Then I got Phenergan, and all the nausea was finally gone. I think, for me, Phenergan is a better anti-nausea medication, but while ondansetron (Zofran) barely made me sleepy, Phenergan made me very sleepy. I actually think, if you are at home or in a hospital, it is much better to take Phenergan as it seems to help more and also gives you a good sleep. If you need to go to work or school, you should take Zofran."

• Rai...
• Taken for less than 1 month
• June 14, 2023

For Nausea/Vomiting "My nurse practitioner put me on this to help with nausea related to my migraines, which are monsters even without the nausea. I've taken Promethazine in the past, but the ondansetron is helping much better because it's quick to absorb (two 4 mg dissolvable tablets every 12 hours as needed) and I can get relief fast. I am also taking prescription vitamin D for a deficiency, once a week, and I suffer from horrid nausea for at least 48 hours after taking that. The ondansetron helps with that, too, and the fact that it makes me sleepy, I'm able to get to sleep and rest. I do wake up occasionally with a small headache, but considering the monster I was dealing with before taking it, I'm not complaining. It's a good medicine."