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Zofran Disease Interactions

There are 2 disease interactions with Zofran (ondansetron).


Ondansetron (applies to Zofran) QT interval prolongation

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hypokalemia, Magnesium Imbalance, Congestive Heart Failure, Arrhythmias

ECG changes including QT interval prolongation have been observed in patients receiving ondansetron. Additionally, there have been some postmarketing reports of Torsade de Pointes cases. The use of ondansetron should be avoided in patients with congenital long QT syndrome. ECG monitoring is recommended in patients with electrolyte abnormalities such as hypokalemia or hypomagnesemia, patients with congestive heart failure, bradyarrhythmias, or patients taking other medicines that could lead to QT prolongation.


  1. (2001) "Product Information. Zofran (ondansetron)." GlaxoSmithKline
  2. (2010) "Product Information. Zuplenz (ondansetron)." Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc.

Ondansetron (applies to Zofran) liver disease

Moderate Potential Hazard, High plausibility.

Ondansetron is extensively metabolized by the liver. The plasma clearance of ondansetron may be substantially decreased and the half-life prolonged in patients with impaired hepatic function. During clinical trials in patients receiving concomitant chemotherapy, transient elevations of serum transaminases and isolated cases of jaundice have been reported. Therapy with ondansetron should be administered cautiously at reduced dosages in patients with liver disease. The manufacturer recommends a maximum daily dosage of 8 mg in severe hepatic impairment.


  1. Finn AL (1992) "Toxicity and side effects of ondansetron." Semin Oncol, 19, p. 53-60
  2. Blake JC, Palmer JL, Minton NA, Burroughs AK (1993) "The pharmacokinetics of intravenous ondansetron in patients with hepatic impairment." Br J Clin Pharmacol, 35, p. 441-3
  3. Colthup PV, Palmer JL (1989) "The determination in plasma and pharmacokinetics of ondansetron." Eur J Cancer Clin Oncol, 25, s71-4
  4. Bryson JC (1992) "Clinical safety of ondansetron." Semin Oncol, 19, p. 26-32
  5. (2001) "Product Information. Zofran (ondansetron)." GlaxoSmithKline
  6. Verrill M, Judson I (1994) "Jaundice with ondansetron." Lancet, 344, p. 190-1
  7. Roila F, Delfavero A (1995) "Ondansetron clinical pharmacokinetics." Clin Pharmacokinet, 29, p. 95-109
  8. Figg WE, Dukes GE, Pritchard JF, et al. (1992) "Ondansetron (OND) pharmacokinetics in chronic liver disease (LD)." Clin Pharmacol Ther, 51, p. 171
  9. Figg WD, Dukes GE, Pritchard JF, Hermann DJ, Lesesne HR, Carson SW, Songer SS, Powell R, Hak LJ (1996) "Pharmacokinetics of ondansetron in patients with hepatic insufficiency." J Clin Pharmacol, 36, p. 206-15
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Zofran drug interactions

There are 347 drug interactions with Zofran (ondansetron).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.