Promethazine Drug Interactions
A total of 1196 drugs are known to interact with promethazine.
- 89 major drug interactions
- 1052 moderate drug interactions
- 55 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for promethazine and the medicines listed below.
- Advil (ibuprofen)
- Ambien (zolpidem)
- azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- codeine
- cyclobenzaprine (Flexeril, Fexmid, Amrix, Comfort Pac with Cyclobenzaprine)
- Cymbalta (duloxetine)
- dextromethorphan (Delsym, Dextromethorphan HBr Adult Formula, Cough Syrup DM, Dry Cough, Delsym 12 Hour Cough Relief, Benylin DM, Bisolvon Dry, Robitussin CoughGels Long-Acting, Calmylin, St. Joseph Cough Suppressant, Strepsils Cough, Sucrets Cough, Creomulsion, Bisolvon Dry Junior, Strepsils Cough Relief, Buckley's DM, Tussin Cough Gels (Long Acting), DexAlone, Robitussin 12-Hour Cough Relief, Pertussin ES, PediaCare Children's Long-Acting Cough, Babee Cof, Silphen DM, Pertussin DM, Vicks Formula 44 Custom Care Dry Cough Suppressant, Balminil DM, Delsym 12 Hour Cough Relief for Children & Adults, Novahistine DM, Covonia Bronchial Balsam, Robitussin Cough Long-Acting, Triaminic Thin Strips Long Acting Cough, Benadryl for the Family Dry Forte, Theraflu Thin Strips Cough, Neocitran Thin Strips Cough, Contac Cough, Robafen Cough Liquidgels, Jack & Jill Thin Strips Cough, Tussinol for Dry Coughs, Dristan DM, Dexi-Tuss, Nucosef DM, Delsym Children's 12-Hour Cough Relief, Buckleys Mixture, Pedia Relief, Triaminic Long Acting Cough, Creomulsion Children, Buckley's Mixture Cough Suppressant, Vicks Nature Fusion Cough, Duract Max Strength Cough, Scot-Tussin Diabetes, Lloydspharmacy Dry Adult Cough, Hold, 12 Hour Cough Relief, Triaminic Thin Strips Cough, Vicks Formula 44, ElixSure Cough, Scot-Tussin DM Cough Chasers, Hold DM, Pertussin CS Childrens, Robitussin Children's Cough Long-Acting, Tussin Pediatric, Robafen Pediatric Cough & Cold, Vicks Dayquil Cough)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
- Klonopin (clonazepam)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- methadone (Dolophine, Methadose, Methadone Diskets, Methadose Sugar-Free)
- naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, EC-Naprosyn, Midol Extended Relief, Flanax Pain Reliever, Aflaxen, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Dazidox, Oxyfast, Oxecta, Oxydose, RoxyBond, Percolone, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
- prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Zydol, Tramahexal, Ryzolt, Tramal SR, ConZip, Larapam SR, GenRx Tramadol, Tramedo, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
- trazodone (Desyrel, Oleptro, Desyrel Dividose)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Promethazine alcohol/food interactions
There is 1 alcohol/food interaction with promethazine
Promethazine disease interactions
There are 18 disease interactions with promethazine which include:
- acute alcohol intoxication
- cardiovascular disease
- CNS depression
- head injury
- antidopaminergic effects 1
- asthma
- anticholinergic effects
- asthma/COPD
- breast cancer
- dystonic reactions
- hematologic toxicity
- liver disease
- NMS
- parkinsonism
- renal dysfunction
- seizure disorders
- tardive dyskinesia
- antidopaminergic effects 2
More about promethazine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Compare Alternatives
- Support Group
- Pricing & Coupons
- 225 Reviews
- Drug class: antihistamines
- FDA Alerts (3)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
