Promethazine Drug Interactions
A total of 1193 drugs are known to interact with promethazine.
- 88 major drug interactions
- 1051 moderate drug interactions
- 54 minor drug interactions
Check for interactions
Most frequently checked interactions
View interaction reports for promethazine and the medicines listed below.
- Advil (ibuprofen)
- Ambien (zolpidem)
- azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
- Benadryl (diphenhydramine)
- Claritin (loratadine)
- codeine
- cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
- Cymbalta (duloxetine)
- dextromethorphan (Delsym, Dextromethorphan HBr Adult Formula, Delsym 12 Hour Cough Relief, Cough Syrup DM, Dry Cough, Robitussin CoughGels Long-Acting, Benylin DM, Bisolvon Dry, Hold DM, Calmylin, Pertussin CS Childrens, Delsym 12 Hour Cough Relief for Children & Adults, Vicks Formula 44, Strepsils Cough, Robafen Cough Liquidgels, Dexi-Tuss, Sucrets Cough, Creomulsion Children, Creomulsion, Tussin Cough Gels (Long Acting), Hold, DexAlone, Robitussin 12-Hour Cough Relief, St. Joseph Cough Suppressant, Vicks Dayquil Cough, Babee Cof, Silphen DM, Pertussin DM, Vicks Formula 44 Custom Care Dry Cough Suppressant, Balminil DM, Novahistine DM, Covonia Bronchial Balsam, Robitussin Cough Long-Acting, Triaminic Thin Strips Long Acting Cough, Benadryl for the Family Dry Forte, Theraflu Thin Strips Cough, Neocitran Thin Strips Cough, Contac Cough, Jack & Jill Thin Strips Cough, Tussinol for Dry Coughs, Bisolvon Dry Junior, Dristan DM, Nucosef DM, Strepsils Cough Relief, Delsym Children's 12-Hour Cough Relief, Buckleys Mixture, Pedia Relief, Triaminic Long Acting Cough, Buckley's DM, Buckley's Mixture Cough Suppressant, Vicks Nature Fusion Cough, Duract Max Strength Cough, Scot-Tussin Diabetes, Lloydspharmacy Dry Adult Cough, 12 Hour Cough Relief, Triaminic Thin Strips Cough, ElixSure Cough, Scot-Tussin DM Cough Chasers, Robitussin Children's Cough Long-Acting, Pertussin ES, PediaCare Children's Long-Acting Cough, Tussin Pediatric, Robafen Pediatric Cough & Cold)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flexeril (cyclobenzaprine)
- hydrocodone (Hysingla ER, Zohydro ER, Vantrela ER)
- Klonopin (clonazepam)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- methadone (Methadose, Methadone Diskets, Dolophine, Methadose Sugar-Free)
- naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, RoxyBond, Percolone, Oxecta, Oxydose, Oxyfast, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol, Dazidox)
- prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
- ProAir HFA (albuterol)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Topamax (topiramate)
- tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
- trazodone (Desyrel, Oleptro, Desyrel Dividose)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Promethazine alcohol/food interactions
There is 1 alcohol/food interaction with promethazine
Promethazine disease interactions
There are 18 disease interactions with promethazine which include:
- anticholinergic effects
- asthma/COPD
- acute alcohol intoxication
- cardiovascular disease
- CNS depression
- head injury
- antidopaminergic effects 1
- asthma
- breast cancer
- dystonic reactions
- hematologic toxicity
- liver disease
- NMS
- parkinsonism
- renal dysfunction
- seizure disorders
- tardive dyskinesia
- antidopaminergic effects 2
More about promethazine
- Promethazine Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Compare Alternatives
- Support Group
- Pricing & Coupons
- 218 Reviews
- Drug class: antihistamines
- FDA Alerts (3)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
