Promethazine Alternatives Compared
| Promethazine | Ondansetron | Zofran |
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| Promethazine | Ondansetron | Zofran ondansetron |
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Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis, Motion Sickness... View more |
Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Prescribed for Nausea/Vomiting, Nausea/Vomiting - Chemotherapy Induced... View more |
Zofran may be used for the treatment and prevention of nausea and vomiting caused by cancer chemotherapy, radiation, or surgery. It is approved for use in adults and children over the age of 4. A... View more |
Choose a suggestion below Nausea/Vomiting
Popular Comparisons
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| More about Promethazine | More about Ondansetron | More about Zofran (ondansetron) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Availability | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Promethazine has an average rating of 7.3 out of 10 from a total of 341 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 21% reported a negative effect. |
Ondansetron has an average rating of 7.7 out of 10 from a total of 440 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 19% reported a negative effect. |
Zofran has an average rating of 8.0 out of 10 from a total of 211 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 16% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See the full promethazine side effects document. |
See the full ondansetron side effects document. |
See the full Zofran side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all promethazine prices |
View all ondansetron prices |
View all Zofran prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Adgan, Anergan 50, Antinaus 50, Phenadoz, Phenergan, Promethegan | Zofran, Zofran ODT, Zuplenz | Other ondansetron brands include: Zofran ODT, Zuplenz | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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16 hours |
4 hours |
4 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 662 drugs are known to interact with promethazine:
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A total of 326 drugs are known to interact with ondansetron:
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A total of 326 drugs are known to interact with Zofran:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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March 29, 1951 |
January 04, 1991 |
December 31, 1992 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.