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Promethazine Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Promethazine Remove Promethazine from your drug comparison Ondansetron Remove Ondansetron from your drug comparison Zofran Remove Zofran from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Promethazine Remove Promethazine from your drug comparison Ondansetron Remove Ondansetron from your drug comparison Zofran ondansetron Remove Zofran from your drug comparison

Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis, Motion Sickness,... View more

Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Prescribed for Nausea/Vomiting, Nausea/Vomiting - Chemotherapy Induced,... View more

Zofran may be used for the treatment and prevention of nausea and vomiting caused by cancer chemotherapy, radiation, or surgery. It is approved for use in children over the age of 4, and a headache,... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 292 reviews

View all 401 reviews

View all 231 reviews

Drug Class

Side Effects

See the full promethazine side effects document.

See the full ondansetron side effects document.

See the full Zofran side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 1 tablet
Dosage 25 mg
Per Unit* $8.24 - $9.70
Cost* $8.24 - $9.70

View all promethazine prices

Quantity 2 mL
Dosage 2 mg/mL
Per Unit* $4.05
Cost* $8.10

View all ondansetron prices

Quantity 3 tablet
Dosage 8 mg
Per Unit* $40.61
Cost* $121.82

View all Zofran prices and generic prices

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Get free Discount Card

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Generic Availability

Yes (this medicine)

Yes (this medicine)

Yes

Dosage Form(s) Available
  • Injectable solution
  • Oral syrup
  • Oral tablet
  • Rectal suppository
  • Injectable solution
  • Oral solution
  • Oral tablet
  • Oral tablet, disintegrating
  • Injectable solution
  • Oral solution
  • Oral tablet

Brand Names
Adgan, Anergan 50, Antinaus 50, Phenadoz, Phenergan, Promethegan Zofran, Zofran ODT, Zuplenz Other ondansetron brands include: Zofran ODT, Zuplenz

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

16 hours

4 hours

4 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (3)

FDA Alerts (5)

FDA Alerts (5)

Drug Interactions

A total of 652 drugs are known to interact with promethazine:

  • 70 major drug interactions (266 brand and generic names)
  • 567 moderate drug interactions (2248 brand and generic names)
  • 15 minor drug interactions (65 brand and generic names)

A total of 316 drugs are known to interact with ondansetron:

  • 116 major drug interactions (419 brand and generic names)
  • 195 moderate drug interactions (762 brand and generic names)
  • 5 minor drug interactions (19 brand and generic names)

A total of 316 drugs are known to interact with Zofran:

  • 116 major drug interactions (419 brand and generic names)
  • 195 moderate drug interactions (762 brand and generic names)
  • 5 minor drug interactions (19 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using promethazine together with alcohol. This can cause uncontrollable... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

March 29, 1951

January 04, 1991

December 31, 1992

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer