Promethazine Alternatives Compared
| Promethazine | Ondansetron | Phenergan |
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| Promethazine | Ondansetron | Phenergan (promethazine) |
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Prescription only
Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect and it may interact with several other drugs including antidepressants, antipsychotics, and other... View more |
Prescription only
Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Prescribed for Nausea/Vomiting, Alcohol Use Disorder, Gastroenteritis... View more |
Prescription only
Phenergan may be used to relieve allergy symptoms, nausea, or as a sleeping aid. Sedation is the main side effect. Occasionally, paradoxical reactions (the opposite of what is to be expected) may... View more |
Related suggestions |
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| More about Promethazine | More about Ondansetron | More about Phenergan (promethazine) | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Promethazine has an average rating of 7.2 out of 10 from a total of 378 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 21% reported a negative effect. |
Ondansetron has an average rating of 7.7 out of 10 from a total of 478 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 19% reported a negative effect. |
Phenergan has an average rating of 7.3 out of 10 from a total of 147 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 23% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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See also: promethazine side effects in more detail. |
See also: ondansetron side effects in more detail. |
See also: Phenergan side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all promethazine prices |
View all ondansetron prices |
View all Phenergan prices and generic prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Adgan, Anergan 50, Antinaus 50, Phenadoz, Phenergan, Promethegan |
N/A |
Other promethazine brands include: Adgan, Anergan 50, Antinaus 50, Phenadoz, Promethegan | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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16 hours |
4 hours |
16 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 677 drugs are known to interact with promethazine:
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A total of 341 drugs are known to interact with ondansetron:
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A total of 677 drugs are known to interact with Phenergan:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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March 29, 1951 |
January 04, 1991 |
March 29, 1951 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.