Comparing Ondansetron vs Promethazine

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Ondansetron

Promethazine

Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Prescribed for Nausea/Vomiting, Nausea/Vomiting - Chemotherapy Induced... View more

Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect. Prescribed for Light Sedation, Allergic Reactions, Allergic Rhinitis, Anaphylaxis, Motion Sickness... View more

Prescription only

Pricing and Coupons

* Prices are without insurance

Quantity	10 mL
Dosage	2 mg/mL
Per Unit^*	$1.46
Cost^*	$14.56

View all ondansetron prices

Quantity	1 tablet
Dosage	25 mg
Per Unit^*	$9.70
Cost^*	$9.70

View all promethazine prices

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Generic Availability

Yes (this medicine)

Dosage Form(s) Available

Injectable solution
Oral solution
Oral tablet
Oral tablet, disintegrating

Injectable solution
Oral syrup
Oral tablet
Rectal suppository

Brand Names

Zofran, Zofran ODT, Zuplenz Adgan, Anergan 50, Antinaus 50, Phenadoz, Phenergan, Promethegan

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

4 hours

16 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 323 drugs are known to interact with ondansetron:

118 major drug interactions (423 brand and generic names)
200 moderate drug interactions (775 brand and generic names)
5 minor drug interactions (19 brand and generic names)

A total of 656 drugs are known to interact with promethazine:

72 major drug interactions (269 brand and generic names)
569 moderate drug interactions (2260 brand and generic names)
15 minor drug interactions (65 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Ask your doctor before using promethazine together with alcohol. This can cause uncontrollable... View more

Disease Interactions

First Approval Date

January 04, 1991

March 29, 1951

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer