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Comparing Ondansetron vs Zofran

Ondansetron

Zofran

ondansetron

Ondansetron may be used for the prevention or treatment of nausea and vomiting but it may cause constipation or a headache. Prescribed for Nausea/Vomiting, Nausea/Vomiting - Chemotherapy Induced,... more

Zofran relieves and prevents nausea and vomiting. Side effects may include constipation and headache. Prescribed for Nausea/Vomiting, Nausea/Vomiting - Chemotherapy Induced, Nausea/Vomiting -... more

Prescription only

Prescription only

Ratings & Reviews

Recent helpful reviews
8.1
305 Reviews

For Nausea/Vomiting I caught a stomach bug around the middle of November and was extremely nauseous. I saw my gastroenterologist who prescribed Ondansetron which helped. I have post infectious IBS thanks to the nasty stomach bug I picked up and experience nausea among other things and this medicine has helped. I hate feeling nauseous.

8
IBSgirl1668

For Nausea/Vomiting I have endometriosis on my bowel that causes almost constant nausea. I usually take Domperidone but when I'm having a particularly bad day/night i needed something stonger. I asked my specialist for it and it took a while to get them to prescribe it. eventually they relented. It didn't take long for me to need it. I was having a very bad night - dry heaves, bad taste in mouth and shakes. I took 1 x 4mg pill and within 10 mins I was feeling almost human...I managed to get to sleep and today I'm at work... This would not have been possible without this little magic pill... the reason for the 8 and not a 10 is because I have only so far used it once.... it worked wonderfully that one time but I'll hold some reservation in case it was a fluke.

8
Fallen_Angel182
8.5
180 Reviews

For Nausea/Vomiting This is such an effective and helpful med. I can't tell you how many times I'd been nauseous and almost immediately got rid of it with the disolvable version. It melts, I wait a few minutes and then it's gone normally.

9
Natty_R

For Nausea/Vomiting I suffer from both severe emetophobia (fear of vomiting) AND a panic disorder which causes nausea and gastric upset. I spent many years trapped in a horrible cycle of panicking any time I felt the slightest twinge of nausea, which in turn, induced intense stomach upset, sometimes to the point of heaving. I've tried other anti-nausea medication in the past (Phenergran, Compazine), with so-so results, and the annoying side effect of extreme drowsiness. Zofran has been a real lifesaver for me. Within minutes of taking a pill, my nausea subsides. The only side effect I've experienced has been constipation, but I'll take that over vomiting any day!

9
Anonymous

View all 305 reviews

View all 180 reviews

Drug Class

Side Effects

See the full ondansetron side effects document.

See the full Zofran side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 2 mL
Dosage 2 mg/mL
Per Unit* $4.05
Cost* $8.10
View all ondansetron prices
Quantity 3 tablet
Dosage 8 mg
Per Unit* $40.61
Cost* $121.82
View all Zofran prices
View generic prices

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available
  • Injectable solution
  • Oral solution
  • Oral tablet
  • Oral tablet, disintegrating
  • Injectable solution
  • Oral solution
  • Oral tablet

Brand Names
Zofran, Zofran ODT, and Zuplenz Other ondansetron brands include: Zofran ODT, and Zuplenz

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

4 hours

4 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (5)

FDA Alerts (5)

Drug Interactions

A total of 536 drugs are known to interact with ondansetron:

  • 202 major drug interactions (1458 brand and generic names)
  • 325 moderate drug interactions (1699 brand and generic names)
  • 9 minor drug interactions (44 brand and generic names)

A total of 536 drugs are known to interact with Zofran:

  • 202 major drug interactions (1458 brand and generic names)
  • 325 moderate drug interactions (1699 brand and generic names)
  • 9 minor drug interactions (44 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No results found - however, this does not necessarily mean no warnings exist. Always consult with your doctor or pharmacist.

No results found - however, this does not necessarily mean no warnings exist. Always consult with your doctor or pharmacist.

Disease Interactions

First Approval Date

January 04, 1991

December 31, 1992

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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