Skip to main content

Zofran and Tiredness: What Users Say

Tiredness: mentioned by 6 users (2.2%)

Based on user experiences from 271 Zofran reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 21.4%
vomiting 15.1%
constipation 12.5%
headaches 7.7%
dizziness 5.5%
drowsiness 3.3%
tiredness 2.2%
diarrhea 1.8%
sleepy 1.8%
tremors 1.5%

Reviews for Zofran

Commonly mentioned side effects
  • Hgg...
  • April 22, 2021

For Nausea/Vomiting "I have hyperemesis gravidarum (HG) and have been miserable. Zofran is keeping me out of the ER right now. At first, I noticed it made me a little dizzy, and it still makes me feel just a little weird within the first hour, but it’s extremely tolerable. The constipation is super annoying, but talk to your doctor about it if that’s an issue, and you can probably take something to help that. It stops me from throwing up, but I am still definitely nauseous. Brings it from like a 10 to a 5 or 6 maybe, but I can EAT now. That is huge. I am eating small meals when I haven’t had a meal in weeks. I’ve been barely eating and drinking. I am completely dependent on Zofran to be any type of functional right now. It makes me a little tired but also gives me more energy to not just stay in bed all day because it makes me feel better. Highly recommend, just watch out for the side effects I mentioned. Nothing to be scared of, extremely tolerable for me :)"

8 / 10
Was this helpful?YesNo
48 Report
  • OLo...
  • Taken for 1 to 2 years
  • May 3, 2014

For Nausea/Vomiting "This medication works wonders for me whenever I feel sick or nauseous. The flavored tablets that disintegrate under the tongue or in the mouth are very convenient and work really quickly to relieve nausea/vomiting. The only real side effect from it that I have noticed is a slight tired feeling. I'd much rather feel a little sleepy than sick to my stomach. I really recommend this medicine if your doctor also feels that it is right for you."

10 / 10
Was this helpful?YesNo
38 Report
  • Smi...
  • Taken for 2 to 5 years
  • March 14, 2022

For Nausea/Vomiting "Zofran is the best drug for nausea! I suffer from Cyclic Vomiting Syndrome, which doctors say is the worst form of nausea. I get extreme nausea that doesn’t get better after vomiting, and each time I have a flare-up, it lasts 12 hours. Zofran is the only thing that will stop it. It makes me a little tired, but I’ll take that any day over the nausea. I use the disintegrating tablets, which are great for when you feel like you can’t swallow a pill from the nausea."

10 / 10
Was this helpful?YesNo
4 Report

Frequently asked questions

  • Aly...
  • Taken for less than 1 month
  • June 3, 2021

For Nausea/Vomiting "I took Zofran on May 3, 2021, to help my nauseated stomach. After a little while when it kicked in, I started feeling very drowsy and tired, and my stomach seemed like it was hurting worse. I now know that this medication, Zofran, is not something for me to take. I want to get better, not worse."

3 / 10
Was this helpful?YesNo
6 Report
  • Ott...
  • Taken for less than 1 month
  • July 8, 2022

For Nausea/Vomiting "I was given this for nausea from gastritis. It really didn't help the nausea, but it did give me a headache, made me very tired, that I had to lay down, and then gave me short, awful nightmares that I woke from with something like an electrical shock. It also made my breathing shallow, and like many, the next day I was very constipated. It was not a pleasant experience all around. I find non-prescription products much better than this for nausea. This made me feel much worse, and I would never use it again."

2 / 10
Was this helpful?YesNo
0 Report
  • Zof...
  • October 29, 2022

For Nausea/Vomiting "Zofran had the opposite side effect on me, making me tired, nauseous with vomiting."

1 / 10
Was this helpful?YesNo
1 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.