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Ondansetron Disease Interactions

There are 2 disease interactions with ondansetron:

Major

Ondansetron (Includes Ondansetron) ↔ Qt Interval Prolongation

Severe Potential Hazard, Moderate plausibility

Applies to: Long QT Syndrome, Hypokalemia, Magnesium Imbalance, Congestive Heart Failure, Arrhythmias

ECG changes including QT interval prolongation have been observed in patients receiving ondansetron. Additionally, there have been some postmarketing reports of Torsade de Pointes cases. The use of ondansetron should be avoided in patients with congenital long QT syndrome. ECG monitoring is recommended in patients with electrolyte abnormalities such as hypokalemia or hypomagnesemia, patients with congestive heart failure, bradyarrhythmias, or patients taking other medicines that could lead to QT prolongation.

Moderate

Ondansetron (Includes Ondansetron) ↔ Liver Disease

Moderate Potential Hazard, High plausibility

Applies to: Liver Disease

Ondansetron is extensively metabolized by the liver. The plasma clearance of ondansetron may be substantially decreased and the half-life prolonged in patients with impaired hepatic function. During clinical trials in patients receiving concomitant chemotherapy, transient elevations of serum transaminases and isolated cases of jaundice have been reported. Therapy with ondansetron should be administered cautiously at reduced dosages in patients with liver disease. The manufacturer recommends a maximum daily dosage of 8 mg in severe hepatic impairment.

References

  1. Colthup PV, Palmer JL "The determination in plasma and pharmacokinetics of ondansetron." Eur J Cancer Clin Oncol 25 (1989): s71-4
  2. Blake JC, Palmer JL, Minton NA, Burroughs AK "The pharmacokinetics of intravenous ondansetron in patients with hepatic impairment." Br J Clin Pharmacol 35 (1993): 441-3
  3. Figg WE, Dukes GE, Pritchard JF, et al. "Ondansetron (OND) pharmacokinetics in chronic liver disease (LD)." Clin Pharmacol Ther 51 (1992): 171
View all 9 references

ondansetron drug Interactions

There are 388 drug interactions with ondansetron

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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