Comparing Phenergan vs Zofran
| Phenergan (promethazine) | Zofran (ondansetron) |
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| Phenergan (promethazine) | Zofran (ondansetron) |
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Prescription only
Phenergan (promethazine) treats allergies, rhinitis, conjunctivitis, nausea, vomiting, and insomnia. The brand is discontinued in the US, but generic versions remain available. Common side effects... View more |
Prescription only
Zofran is used to prevent nausea and vomiting caused by cancer chemotherapy, radiotherapy, or surgery. It is approved for use in adults and children over the age of 4 and is available as tablets... View more |
Related suggestions Nausea/Vomiting
Popular comparisons
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| More about Phenergan (promethazine) | More about Zofran (ondansetron) | ||||||||
| Ratings & Reviews | |||||||||
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Phenergan has an average rating of 7.4 out of 10 from a total of 153 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 21% reported a negative effect. |
Zofran has an average rating of 8.0 out of 10 from a total of 273 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 15% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Phenergan side effects |
View all Zofran side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
| Pricing and Coupons * Prices are without insurance | |||||||||
View all Phenergan prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | |||||||||
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| Brand Names | |||||||||
| Other promethazine brands include: Adgan, Anergan 50, Antinaus 50, Phenadoz, Promethegan |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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16 hours |
4 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 691 drugs are known to interact with Phenergan:
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A total of 364 drugs are known to interact with Zofran:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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March 29, 1951 |
December 31, 1992 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.