Comparing Cyclobenzaprine vs Orphenadrine
| Cyclobenzaprine | Orphenadrine |
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| Cyclobenzaprine | Orphenadrine |
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Prescription only
Cyclobenzaprine is a muscle relaxant that may be used short-term to treat muscle spasms caused by musculoskeletal conditions, in addition to rest and physical therapy. Sedation is a common side... View more |
Prescription only
Prescribed for Muscle Spasm, Migraine, Headache. Orphenadrine may also be used for purposes not listed in this medication guide. |
Related suggestions Migraine
Muscle Spasm (Involuntary Hypertonicity)
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| More about Cyclobenzaprine | More about Orphenadrine | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Cyclobenzaprine has an average rating of 6.0 out of 10 from a total of 618 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 30% reported a negative effect. |
Orphenadrine has an average rating of 6.7 out of 10 from a total of 83 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 28% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Cyclobenzaprine side effects |
View all Orphenadrine side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Cyclobenzaprine prices |
View all Orphenadrine prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Amrix, Comfort Pac with Cyclobenzaprine |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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72 hours |
16 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 451 drugs are known to interact with Cyclobenzaprine:
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A total of 399 drugs are known to interact with Orphenadrine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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August 26, 1977 |
November 04, 1959 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.