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Orphenadrine Disease Interactions

There is 1 disease interaction with orphenadrine.


Orphenadrine (applies to orphenadrine) anticholinergic effects

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction, Glaucoma/Intraocular Hypertension, Myasthenia Gravis, Urinary Retention, Esophageal Obstruction

Orphenadrine has mild anticholinergic activity, to which elderly patients are particularly sensitive. The manufacturer considers the use of orphenadrine to be contraindicated in patients with glaucoma, pyloric or duodenal obstruction, achalasia, prostatic hypertrophy, bladder neck obstruction, or myasthenia gravis. Orphenadrine should be used cautiously in other conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention and gastrointestinal obstructive disorders.


  1. "Product Information. Norflex (orphenadrine)." 3M Pharmaceuticals (2001):

Orphenadrine drug interactions

There are 369 drug interactions with orphenadrine.

Orphenadrine alcohol/food interactions

There is 1 alcohol/food interaction with orphenadrine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.