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Orphenadrine and Drowsiness: What Users Say

Drowsiness: mentioned by 5 users (6.0%)

Based on user experiences from 83 Orphenadrine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

anxiety 12.0%
dry mouth 9.6%
dizziness 8.4%
drowsiness 6.0%
lightheadedness 6.0%
tremors 6.0%
nausea 4.8%
headaches 3.6%
irritability 3.6%

Reviews for Orphenadrine

Commonly mentioned side effects
  • Nur...
  • Taken for 2 to 5 years
  • November 8, 2012

Orphenadrine for Muscle Spasm "I was given this while living in the Philippines as a combo med with Acetaminophen. It worked better than any pain medicine I had ever used without the side effects of stomach upset (Ibuprofen) or fatigue, sleepiness (codeine)."

9 / 10
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81 Report
  • Rox...
  • Taken for less than 1 month
  • August 16, 2021

Orphenadrine for Muscle Spasm "A pharmacist gave me Brufen tablets to take during the day and Norflex at night. I took one tablet of Norflex before bed, only to wake up in the middle of the night in pain again, and it felt worse. I decided to take another tablet so that I could sleep again, but two hours later, I woke up with the urge to go to the bathroom. I laid there paralyzed, and it felt like my brain was swimming in my skull. I couldn't even speak to warn my partner about how I was feeling. Eventually, I rolled onto my side, grabbing the wall next to my bed to help me get up. It's been 11 hours since I took the last pill, and I am still feeling the effects of it. The effects I experienced so far with it are dry mouth, unbalanced, confused, difficulty with speech, very sleepy, and being paralyzed."

1 / 10
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19 Report
  • Gwe...
  • Taken for 10 years or more
  • October 27, 2013

For Muscle Spasm "Thoracic and lumbar issues cause constant muscle spasms. Orphenadrine E.R. helps tame them. It is also the least of the evils when it comes to causing drowsiness."

10 / 10
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39 Report

See also:

  • vau...
  • April 19, 2010

Orphenadrine for Migraine "Made me blurry, drowsy, and cognitive dulling. Short trial only (two weeks), then stopped due to side effects."

3 / 10
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48 Report
  • Dan...
  • February 28, 2016

For Muscle Spasm "Best tablet I've ever been given for severe muscle spasms. Did make me very groggy, fell asleep sitting up at night numerous times as couldn't stay up past 8 pm."

10 / 10
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12 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.