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Amitriptyline Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Amitriptyline Topiramate Topamax
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Amitriptyline Topiramate Topamax (topiramate)
Prescription only

Amitriptyline is an effective antidepressant but may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. Prescribed for Chronic Myofascial Pain, Anxiety and Stress... View more

Prescription only

Topiramate may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraines. Drowsiness is a... View more

Prescription only

Topamax may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraine. Drowsiness is a... View more

More about Amitriptyline More about Topiramate More about Topamax (topiramate)
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

Amitriptyline has an average rating of 7.5 out of 10 from a total of 1634 ratings on Drugs.com. 68% of reviewers reported a positive effect, while 17% reported a negative effect.

Topiramate has an average rating of 6.3 out of 10 from a total of 1235 ratings on Drugs.com. 52% of reviewers reported a positive effect, while 29% reported a negative effect.

Topamax has an average rating of 6.2 out of 10 from a total of 557 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 30% reported a negative effect.

View all 1634 reviews

View all 1235 reviews

View all 557 reviews

Drug Class
Side Effects

See also: amitriptyline side effects in more detail.

Commonly reported side effects include:

  • anxiety
  • ataxia
  • confusion
  • diarrhea
  • diplopia
  • dizziness
  • drowsiness
  • dysphasia
  • fatigue
  • lack of concentration
  • memory impairment
  • nausea
  • nervousness
  • paresthesia
  • psychomotor disturbance
  • speech disturbance
  • depression
  • visual disturbance
  • weight loss
  • dysgeusia
  • mood changes
  • anorexia
  • show all 22

See also: topiramate side effects in more detail.

Common side effects include:

  • anxiety
  • ataxia
  • confusion
  • diarrhea
  • diplopia
  • dizziness
  • drowsiness
  • dysphasia
  • fatigue
  • lack of concentration
  • memory impairment
  • nausea
  • nervousness
  • paresthesia
  • psychomotor disturbance
  • speech disturbance
  • depression
  • visual disturbance
  • weight loss
  • dysgeusia
  • mood changes
  • anorexia
  • show all 22

See also: Topamax side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 100 each
Dosage 25 mg
Per Unit* $0.24
Cost* $23.52

View all amitriptyline prices

Quantity 7 tablet
Dosage 100 mg
Per Unit* $2.52
Cost* $17.61

View all topiramate prices

Quantity 60 tablet
Dosage 100 mg
Per Unit* $18.60
Cost* $1,115.82

View all Topamax prices and generic prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Oral tablet
  • Oral capsule
  • Oral capsule, extended release
  • Oral tablet
  • Oral tablet
Brand Names

N/A

 Eprontia, Qudexy XR, Topamax, Trokendi XR Other topiramate brands include: Eprontia, Qudexy XR, Trokendi XR
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

16 hours

56 hours

56 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
D
Category D Positive evidence of risk

See the full pregnancy warnings document.
Drug Interactions

A total of 668 drugs are known to interact with amitriptyline:

  • 133 major drug interactions (574 brand and generic names)
  • 509 moderate drug interactions (2008 brand and generic names)
  • 26 minor drug interactions (165 brand and generic names)

A total of 285 drugs are known to interact with topiramate:

  • 104 major drug interactions (626 brand and generic names)
  • 178 moderate drug interactions (685 brand and generic names)
  • 3 minor drug interactions (12 brand and generic names)

A total of 285 drugs are known to interact with Topamax:

  • 104 major drug interactions (626 brand and generic names)
  • 178 moderate drug interactions (685 brand and generic names)
  • 3 minor drug interactions (12 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using amitriptyline together with alcohol, this can alter the effects of... View more
  • Ask your doctor before using alcohol together with topiramate. This can cause excessive sleep... View more
  • Ask your doctor before using alcohol together with topiramate. This can cause excessive sleep... View more
Disease Interactions
First Approval Date

April 07, 1961

December 24, 1996

December 24, 1996
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources

N/A
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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