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Amitriptyline Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Amitriptyline Remove Amitriptyline from your drug comparison Topiramate Remove Topiramate from your drug comparison Topamax Remove Topamax from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Amitriptyline Remove Amitriptyline from your drug comparison Topiramate Remove Topiramate from your drug comparison Topamax topiramate Remove Topamax from your drug comparison

Amitriptyline is an effective antidepressant but may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. Prescribed for Chronic Myofascial Pain, Anxiety and Stress,... View more

Topiramate may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraines. Drowsiness is a... View more

Topamax may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraine. Drowsiness is a... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 1458 reviews

View all 1140 reviews

View all 519 reviews

Drug Class

Side Effects

See the full amitriptyline side effects document.

Commonly reported side effects include: anxiety, ataxia, confusion, diarrhea, diplopia, dizziness, drowsiness, dysphasia, fatigue, lack of concentration, memory impairment, nausea, nervousness, paresthesia, psychomotor disturbance, speech disturbance, depression, visual disturbance, weight loss, dysgeusia, mood changes, anorexia.

See the full topiramate side effects document.

Common side effects include: anxiety, ataxia, confusion, diarrhea, diplopia, dizziness, drowsiness, dysphasia, fatigue, lack of concentration, memory impairment, nausea, nervousness, paresthesia, psychomotor disturbance, speech disturbance, depression, visual disturbance, weight loss, dysgeusia, mood changes, anorexia.

See the full Topamax side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 100 each
Dosage 25 mg
Per Unit* $0.28
Cost* $27.68

View all amitriptyline prices

Quantity 7 tablet
Dosage 50 mg
Per Unit* $2.29
Cost* $16.05

View all topiramate prices

Quantity 60 tablet
Dosage 100 mg
Per Unit* $18.08
Cost* $1,084.85

View all Topamax prices and generic prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes (this medicine)

Yes

Dosage Form(s) Available
  • Oral tablet
  • Oral capsule
  • Oral capsule, extended release
  • Oral tablet
  • Oral tablet

Brand Names

N/A

 Qudexy XR, Topamax, Trokendi XR Other topiramate brands include: Qudexy XR, Trokendi XR

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

16 hours

56 hours

56 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
D
Category D Positive evidence of risk

See the full Pregnancy Warnings document.
D
Category D Positive evidence of risk

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (1)

FDA Alerts (3)

FDA Alerts (6)

Drug Interactions

A total of 649 drugs are known to interact with amitriptyline:

  • 120 major drug interactions (467 brand and generic names)
  • 502 moderate drug interactions (1966 brand and generic names)
  • 27 minor drug interactions (174 brand and generic names)

A total of 264 drugs are known to interact with topiramate:

  • 96 major drug interactions (557 brand and generic names)
  • 165 moderate drug interactions (636 brand and generic names)
  • 3 minor drug interactions (12 brand and generic names)

A total of 264 drugs are known to interact with Topamax:

  • 96 major drug interactions (557 brand and generic names)
  • 165 moderate drug interactions (636 brand and generic names)
  • 3 minor drug interactions (12 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using amitriptyline together with alcohol, this can alter the effects of... View more
  • Ask your doctor before using alcohol together with topiramate. This can cause excessive sleep,... View more
  • Ask your doctor before using alcohol together with topiramate. This can cause excessive sleep,... View more

Disease Interactions

First Approval Date

April 07, 1961

December 24, 1996

December 24, 1996

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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