Lofexidine Alternatives Compared
| Lofexidine | Methadone | Clonidine |
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| Lofexidine | Methadone | Clonidine |
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Prescription only
Lofexidine is used to ease the symptoms due to abruptly stopping opioids in people with opioid addiction (opioid use disorder). It is given for up to 14 days, based on symptoms and peak withdrawal... View more |
Prescription only
Methadone is a potent opioid analgesic that may be used to relieve severe pain unresponsive to other strong pain relievers; however, it is more commonly used to treat opioid addiction. There is a... View more |
Prescription only
Clonidine can be used to lower blood pressure and extended-release forms are used to treat ADHD; however, it causes sedation, and tolerance can develop to its blood pressure-lowering effects... View more |
Related suggestions Opiate Withdrawal
Popular comparisons
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| More about Lofexidine | More about Methadone | More about Clonidine | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Lofexidine has an average rating of 6.6 out of 10 from a total of 50 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 32% reported a negative effect. |
Methadone has an average rating of 8.7 out of 10 from a total of 606 ratings on Drugs.com. 84% of reviewers reported a positive effect, while 6% reported a negative effect. |
Clonidine has an average rating of 7.1 out of 10 from a total of 774 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Lofexidine side effects |
View all Methadone side effects |
View all Clonidine side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Lofexidine prices |
View all Methadone prices |
View all Clonidine prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Lucemyra | Methadone Diskets, Methadose, Methadose Sugar-Free | Catapres, Catapres-TTS, Clonidine ER, Duraclon, Kapvay, Nexiclon XR, Onyda XR | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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12 hours |
30 hours |
15 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 551 drugs are known to interact with Lofexidine:
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A total of 836 drugs are known to interact with Methadone:
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A total of 375 drugs are known to interact with Clonidine:
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| First Approval Date | ||||||||||||||||||||||||||
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May 16, 2018 |
August 13, 1947 |
September 03, 1974 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
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| More Information | ||||||||||||||||||||||||||
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| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.