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Lofexidine and Tiredness: What Users Say

Brand names: Lucemyra

Tiredness: mentioned by 6 users (12.0%)

Based on user experiences from 50 Lofexidine reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dizziness 18.0%
tremors 16.0%
dry mouth 12.0%
tiredness 12.0%
blood pressure 10.0%
drowsiness 10.0%
loss of appetite 8.0%
fainting 6.0%
fatigue 6.0%
high blood pressure 6.0%

Reviews for Lofexidine

Commonly mentioned side effects
  • Tay...
  • Taken for less than 1 month
  • December 22, 2019

For Opiate Withdrawal "Ok. Now I was on opiates and then methadone. I'm in my late 20s and I'm a teeny tiny female. I was up to 120mg and was on methadone for almost 5 years. I was trying to find any way I could to detox myself. I tapered off the methadone from 120 to 4mg over a span of time. It was too much for me at the end. I did research and found Lucemyra. I read these reviews and it scared me. I'm sorry people had a bad experience but I'm here to let people know this drug changed my life. I'm now clean and sober off methadone and it is 100% because of this drug. Side note, this is a blood pressure med so yes, it will sometimes make you feel very woozy/tired but you can get through it. I worked through it!! Also, this drug unfortunately is very expensive, with my insurance it was to cost $1700. BUT PEOPLE VERY IMPORTANT!! Download the Luminate app and call Aspen pharmacy, they will mail you the drug for $25!! If I got through this you can too, I will advocate this drug forever. It changed my life."

9 / 10
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196 Report
  • Che...
  • Taken for 10 years or more
  • July 6, 2021

For Opiate Withdrawal "I was given this to use to come off of Suboxone. I have been on drugs for as long as I can remember. I quit and started Suboxone and took it for a little more than a year. Once I was down to 2 mgs, I came off the Suboxone. I used these pills, and it was such a blessing. I was able to function completely. I did still feel a little tired, and I could tell when the pill wore off, but I cannot believe it worked so well. I am so grateful. Thank you."

10 / 10
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31 Report
  • cra...
  • Taken for less than 1 month
  • February 19, 2025

For Opiate Withdrawal "This was an absolute game changer for me. I went from oxy to fentanyl, and this saved me. I lost it for three days in the middle of withdrawals, and thank goodness I found it. I never could have gotten clean without this medication. I opted for this over Suboxone and recommend it to everyone I meet struggling with that kind of addiction. It will make you tired, but you can start taking less and less, and it is a short-term medication."

9 / 10
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Frequently asked questions

  • Tho...
  • Taken for less than 1 month
  • March 23, 2023

For Opiate Withdrawal "I had spent 20 years on Subutex, a.k.a. Suboxone. I tampered myself down to 4 mg for the past 3 years, and I used Lucemyra to get off finally, and it did wonders. No restless leg syndrome, no cold hot flashes, no creepy crawling feeling, and I am a little over 2 weeks with no subs, and I feel great. Yes, this medication makes you so tired you don’t even want to get up to walk to the bathroom, but I will take that all day over feeling withdrawal symptoms. The last time I got off subs, I was just off of 24 mg a day with nothing, I didn’t even take Tylenol. It was the worst experience of my life. I have been reading reviews about some people taking Lucemyra who had to go to the hospital. I guess it’s hit or miss with some people on this drug, but I would say give it a try. It’s only money, and yes, a lot of money. Cost me $2,500 to fill 96 pills, but there are programs if you go to the Lucemyra website to get it for as little as $300."

10 / 10
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  • Mil...
  • Taken for less than 1 month
  • June 10, 2023

For Opiate Withdrawal "It helped take the withdrawals away. But sent me to the hospital twice, about to die. It lowered my potassium and magnesium, which caused my heart rate to drop down to 44. I was given shots of atropine in an IV, which brought me back up. Stayed in the hospital for 5 days. Had a few EKGs, which showed my heart was not beating right. Was literally about to die. In the hospital, they put me on clonidine, and I got better. Lucemyra gave me a severely dry mouth, dizziness, no appetite, weakness, could barely walk, food tasted weird, and just no energy. I felt disassociated and had super high blood pressure. It may work for some, but for me, there are too many risks, I’ll stick with clonidine."

2 / 10
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  • EmB...
  • Taken for 1 to 6 months
  • July 22, 2024

For Opiate Withdrawal "I take this as my go-to (with methocarbamol secondarily depending on the symptoms). The two together cover pretty much all the withdrawal symptoms I experience. Was on Suboxone from 9/2022 - 2/2024. Started brixadi shots to wean off films and have the Suboxone leave very slowly. Stopped after four months. Since then, it took about a month for the symptoms to start. Apart from being a bit tired when I take the two close in time, together there are no symptoms and all has been great. Highly recommend the combo."

10 / 10
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