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Baclofen Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Baclofen Remove Baclofen from your drug comparison Cyclobenzaprine Remove Cyclobenzaprine from your drug comparison Tizanidine Remove Tizanidine from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Baclofen Remove Baclofen from your drug comparison Cyclobenzaprine Remove Cyclobenzaprine from your drug comparison Tizanidine Remove Tizanidine from your drug comparison

Baclofen relieves muscle spasm associated with multiple sclerosis and spinal cord injury or disease, but its use is limited by its ability to cause sedation and increase seizure risk. Prescribed for... View more

Cyclobenzaprine is a muscle relaxant that may be used short-term to treat muscle spasms caused by musculoskeletal conditions, in addition to rest and physical therapy. Sedation is a common side... View more

Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation. The dosage should be individualized and because it only lasts for a short time in the body, can be... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 355 reviews

View all 527 reviews

View all 302 reviews

Drug Class

Side Effects

Commonly reported side effects include: drowsiness.

See the full baclofen side effects document.

See the full cyclobenzaprine side effects document.

Commonly reported side effects include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, xerostomia.

See the full tizanidine side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 10 tablet
Dosage 10 mg
Per Unit* $1.30
Cost* $13.00

View all baclofen prices

Quantity 3 tablet
Dosage 10 mg
Per Unit* $2.97 - $3.46
Cost* $8.92 - $10.38

View all cyclobenzaprine prices

Quantity 50 each
Dosage 4 mg
Per Unit* $0.63
Cost* $31.48

View all tizanidine prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes (this medicine)

Yes (this medicine)

Dosage Form(s) Available
  • Intrathecal solution
  • Oral tablet
  • Oral capsule, extended release
  • Oral tablet
  • Oral capsule
  • Oral tablet

Brand Names
Gablofen, Lioresal, Lioresal Intrathecal, Ozobax Amrix, Comfort Pac with Cyclobenzaprine, Fexmid Zanaflex

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

6.8 hours

72 hours

2.5 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (3)

FDA Alerts (1)

FDA Alerts (1)

Drug Interactions

A total of 347 drugs are known to interact with baclofen:

  • 25 major drug interactions (140 brand and generic names)
  • 321 moderate drug interactions (1267 brand and generic names)
  • 1 minor drug interactions (2 brand and generic names)

A total of 375 drugs are known to interact with cyclobenzaprine:

  • 78 major drug interactions (351 brand and generic names)
  • 292 moderate drug interactions (1151 brand and generic names)
  • 5 minor drug interactions (11 brand and generic names)

A total of 575 drugs are known to interact with tizanidine:

  • 225 major drug interactions (807 brand and generic names)
  • 348 moderate drug interactions (1393 brand and generic names)
  • 2 minor drug interactions (11 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Alcohol can increase the nervous system side effects of baclofen such as dizziness, drowsiness, and... View more
  • Alcohol can increase the nervous system side effects of cyclobenzaprine such as dizziness,... View more
  • Using tiZANidine together with alcohol may increase side effects such as dizziness, drowsiness,... View more

Disease Interactions

First Approval Date

November 22, 1977

August 26, 1977

November 27, 1996

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer