Baclofen Alternatives Compared
| Baclofen | Cyclobenzaprine | Tizanidine |
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| Baclofen | Cyclobenzaprine | Tizanidine |
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Baclofen relieves muscle spasms associated with multiple sclerosis and spinal cord injury or disease, but its use is limited by its ability to cause sedation and increase seizure risk. Prescribed for... View more |
Cyclobenzaprine is a muscle relaxant that may be used short-term to treat muscle spasms caused by musculoskeletal conditions, in addition to rest and physical therapy. Sedation is a common side... View more |
Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation. The dosage should be individualized and because it only lasts for a short time in the body, can be... View more |
Choose a suggestion below |
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| More about Baclofen | More about Cyclobenzaprine | More about Tizanidine | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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Prescription only |
Prescription only |
Prescription only |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Baclofen has an average rating of 6.9 out of 10 from a total of 386 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 25% reported a negative effect. |
Cyclobenzaprine has an average rating of 6.0 out of 10 from a total of 558 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 30% reported a negative effect. |
Tizanidine has an average rating of 6.2 out of 10 from a total of 317 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 29% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Commonly reported side effects include: drowsiness. See the full baclofen side effects document. |
See the full cyclobenzaprine side effects document. |
Commonly reported side effects include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, xerostomia. See the full tizanidine side effects document. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all baclofen prices |
View all cyclobenzaprine prices |
View all tizanidine prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Fleqsuvy, Gablofen, Lioresal, Lioresal Intrathecal, Lyvispah, Ozobax | Amrix, Comfort Pac with Cyclobenzaprine | Zanaflex | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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6.8 hours |
72 hours |
2.5 hours |
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| CSA Schedule** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category B
No proven risk in humans
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 355 drugs are known to interact with baclofen:
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A total of 392 drugs are known to interact with cyclobenzaprine:
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A total of 584 drugs are known to interact with tizanidine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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November 22, 1977 |
August 26, 1977 |
November 27, 1996 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.