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Baclofen Disease Interactions

There are 4 disease interactions with baclofen:

Major

Baclofen (Includes baclofen) ↔ renal dysfunction

Severe Potential Hazard, High plausibility. Applies to: Renal Dysfunction

Baclofen is primarily eliminated by the kidney. Patients with impaired renal function may be at greater risk for adverse effects from baclofen due to decreased drug clearance. Therapy with baclofen should be administered cautiously in such patients. Dosage adjustments may be necessary.

References

  1. Himmelsbach FA, Kohler E, Zanker B "Toxic effect of baclofen in chronic haemodialysis and renal transplantation." Dtsch Med Wochenschr 117 (1992): 733-7
  2. Krahn A, Penner SB "Use of baclofen for intractable hiccups in uremia." Am J Med 96 (1994): 391
  3. "Product Information. Lioresal (baclofen)." Medtronic Inc, Minneapolis, MN.
Moderate

Baclofen (Includes baclofen) ↔ autonomic dysreflexia

Moderate Potential Hazard, Moderate plausibility. Applies to: Autonomic Dysreflexia

Therapy with intrathecal baclofen should be administered cautiously in patients with a history of autonomic dysreflexia, since the presence of nociceptive stimuli or abrupt withdrawal of the medication may trigger an episode of dysreflexia.

References

  1. "Product Information. Lioresal Intrathecal (baclofen)." Medtronic Inc, Minneapolis, MN.
Moderate

Baclofen (Includes baclofen) ↔ psychoses

Moderate Potential Hazard, Moderate plausibility. Applies to: Psychosis, History - Psychiatric Disorder

Baclofen may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with baclofen should be administered cautiously in patients with a history of psychiatric disorders.

References

  1. Sommer BR, Petrides G "A case of baclofen-induced psychotic depression." J Clin Psychiatry 53 (1992): 211-2
  2. Penn RD "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg 77 (1992): 236-40
  3. "Product Information. Lioresal (baclofen)." Medtronic Inc, Minneapolis, MN.
  4. Kirubakaran V, Mayfield D, Rengachary S "Dyskinesia and psychosis in a patient following baclofen withdrawal." Am J Psychiatry 141 (1984): 692-3
  5. Siegfried RN, Jacobson L, Chabal C "Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity." Anesthesiology 77 (1992): 1048-50
  6. Stewart JT "A case of mania associated with high-dose baclofen therapy." J Clin Psychopharmacol 12 (1992): 215-7
  7. Lees AJ, Clarke CR, Harrison MJ "Hallucinations after sudden withdrawal of baclofen." Lancet 2 (1977): 44-5
  8. Wolf ME, Almy G, Toll M, Mosnaim AD "Mania associated with the use of baclofen." Biol Psychiatry 17 (1982): 757-9
  9. Terrence CF, Fromm GH "Complications of baclofen withdrawal." Arch Neurol 38 (1981): 588-9
  10. Garabedian-Ruffalo SM, Ruffalo RL "Adverse effects secondary to baclofen withdrawal." Drug Intell Clin Pharm 19 (1985): 304-6
  11. Yassa RY, Iskandar HL "Baclofen-induced psychosis: two cases and a review." J Clin Psychiatry 49 (1988): 318-20
  12. Sandyk R, Gillman MA "Baclofen-induced memory impairment." Clin Neuropharmacol 8 (1985): 294-5
  13. Rivas DA, Chancellor MB, Hill K, Freedman MK "Neurological manifestations of baclofen withdrawal." J Urol 150 (1993): 1903-5
  14. Arnold ES, Rudd SM, Kirshner H "Manic psychosis following rapid withdrawal from baclofen." Am J Psychiatry 137 (1980): 1466-7
  15. Jamous A, Kennedy P, Psychol C, Grey N "Psychological and emotional effects of the use of oral baclofen - a preliminary study." Paraplegia 32 (1994): 349-53
View all 15 references
Moderate

Baclofen (Includes baclofen) ↔ seizure disorders

Moderate Potential Hazard, Moderate plausibility. Applies to: Seizures

Deterioration in seizure control and electroencephalographic (EEG) changes have been reported occasionally in epileptic patients treated with baclofen. Therapy with baclofen should be administered cautiously in patients with a history of seizures. Clinical status and EEG should be monitored at regular intervals during treatment. Except in cases of overdose or severe adverse reactions, cessation of baclofen therapy, whenever necessary, should occur gradually with incrementally reduced dosages. Abrupt withdrawal has been associated with central nervous system effects including seizures, hallucinations, and psychosis.

References

  1. Kirubakaran V, Mayfield D, Rengachary S "Dyskinesia and psychosis in a patient following baclofen withdrawal." Am J Psychiatry 141 (1984): 692-3
  2. Penn RD "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg 77 (1992): 236-40
  3. "Product Information. Lioresal (baclofen)." Medtronic Inc, Minneapolis, MN.
  4. Terrence CF, Fromm GH "Complications of baclofen withdrawal." Arch Neurol 38 (1981): 588-9
  5. Abarbanel J, Herishanu Y, Frisher S "Encephalopathy associated with baclofen." Ann Neurol 17 (1985): 617-8
  6. Lees AJ, Clarke CR, Harrison MJ "Hallucinations after sudden withdrawal of baclofen." Lancet 2 (1977): 44-5
  7. Kofler M, Arturo Leis A "Prolonged seizure activity after baclofen withdrawal." Neurology 42 (1992): 697-8
  8. Hormes JT, Benarroch EE, Rodriguez M, Klass DW "Periodic sharp waves in baclofen-induced encephalopathy." Arch Neurol 45 (1988): 814-5
  9. Arnold ES, Rudd SM, Kirshner H "Manic psychosis following rapid withdrawal from baclofen." Am J Psychiatry 137 (1980): 1466-7
  10. Rush JM, Gibberd FB "Baclofen-induced epilepsy." J R Soc Med 83 (1990): 115-6
  11. Siegfried RN, Jacobson L, Chabal C "Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity." Anesthesiology 77 (1992): 1048-50
  12. Rivas DA, Chancellor MB, Hill K, Freedman MK "Neurological manifestations of baclofen withdrawal." J Urol 150 (1993): 1903-5
  13. Barker I, Grant IS "Convulsions after abrupt withdrawal of baclofen." Lancet 2 (1982): 556-7
  14. Garabedian-Ruffalo SM, Ruffalo RL "Adverse effects secondary to baclofen withdrawal." Drug Intell Clin Pharm 19 (1985): 304-6
  15. Zak R, Solomon G, Petito F, Labar D "Baclofen-induced generalized nonconvulsive status epilepticus." Ann Neurol 36 (1994): 113-4
View all 15 references

Baclofen drug interactions

There are 763 drug interactions with baclofen

Baclofen alcohol/food interactions

There is 1 alcohol/food interaction with baclofen

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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