Azithromycin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Azithromycin	Doxycycline	Azithromycin Dose Pack (azithromycin)	Enter another drug to compare

Azithromycin

Doxycycline

Azithromycin Dose Pack (azithromycin)

Prescription only

Azithromycin is an antibiotic used to treat a variety of different infections. It has the distinct advantage of once-daily dosing; however, diarrhea is a common side effect. Prescribed for Bacterial... View more

Prescription only

Doxycycline is an effective antibiotic that treats a wide range of infections. However, it is not usually recommended for children aged less than eight or pregnant women in the last half of their... View more

Prescription only

Prescribed for Bacterial Infection, Bacterial Endocarditis Prevention, Babesiosis, Bartonellosis, Bronchitis, Cervicitis, Chancroid, Chlamydia Infection, COPD - Acute, Cystic Fibrosis, Gonococcal... View more

More about Azithromycin

More about Doxycycline

More about Azithromycin Dose Pack (azithromycin)

Ratings & Reviews

Azithromycin has an average rating of 6.8 out of 10 from a total of 1308 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 22% reported a negative effect.

Doxycycline has an average rating of 6.4 out of 10 from a total of 1641 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 27% reported a negative effect.

Azithromycin Dose Pack has an average rating of 5.7 out of 10 from a total of 68 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 38% reported a negative effect.

View all 1308 reviews

View all 1641 reviews

View all 68 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Diarrhea (30.7%)
Nausea (23.8%)
Upset stomach (15.1%)
Stomach pain (13.1%)
Headaches (7.4%)
Vomiting (7.2%)
Cramps (6.4%)

View all Azithromycin side effects

Nausea (19.9%)
Headaches (9.6%)
Acne (7.9%)
Vomiting (7.7%)
Upset stomach (5.4%)
Diarrhea (3.2%)
Dizziness (3.2%)

View all Doxycycline side effects

Diarrhea (19.1%)
Nausea (10.3%)
Vomiting (8.8%)
Dizziness (7.4%)
Headaches (7.4%)
Tiredness (5.9%)
Anxiety (4.4%)

View all Azithromycin Dose Pack side effects

Drug Class

Macrolides

Macrolides

Generic Availability

Lower cost generic

Lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	4 tablet
Strength	250 mg
Per unit^*	$4.22 - $4.40
Cost^*	$16.86 - $17.61

View all Azithromycin prices

Quantity	2 tablet
Strength	hyclate 100 mg
Per unit^*	$6.62
Cost^*	$13.23

View all Doxycycline prices

Quantity	18 each
Strength	250 mg
Per unit^*	$2.70
Cost^*	$48.53

View all Azithromycin Dose Pack prices

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Dosage Forms

Intravenous powder for injection
Oral powder for reconstitution
Oral tablet

Injectable powder for injection
Oral capsule
Oral delayed release capsule
Oral delayed release tablet
Oral powder for reconstitution
Oral tablet

Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

53 hours

23 hours

53 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category B No proven risk in humans

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 380 drugs are known to interact with Azithromycin:

83 major drug interactions (246 brand and generic names)
274 moderate drug interactions (1109 brand and generic names)
23 minor drug interactions (72 brand and generic names)

A total of 237 drugs are known to interact with Doxycycline:

22 major drug interactions (60 brand and generic names)
210 moderate drug interactions (2251 brand and generic names)
5 minor drug interactions (21 brand and generic names)

A total of 380 drugs are known to interact with Azithromycin Dose Pack:

83 major drug interactions (246 brand and generic names)
274 moderate drug interactions (1109 brand and generic names)
23 minor drug interactions (72 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

November 01, 1991

December 05, 1967

N/A

WADA Class View classifications

N/A

More Information

Patient Resources

Doxycycline uses

Azithromycin Dose Pack uses

Professional Resources

N/A

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Azithromycin Alternatives Compared

See also:

Cefdinir

Amoxicillin/clavulanate

Dupixent

Levofloxacin

Augmentin

Ceftriaxone

Clindamycin

Metronidazole

Ciprofloxacin

Cephalexin

Further information

Azithromycin Alternatives Compared

See also:

Further information

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