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Azithromycin Pregnancy and Breastfeeding Warnings

Azithromycin is also known as: Azithromycin Dose Pack, Z-Pak, Zithromax, Zmax

Azithromycin Pregnancy Warnings

In one study comparing azithromycin and erythromycin, 15 pregnant women received one gram of azithromycin for the treatment of chlamydial infection. The period of gestation during which the drugs were given was not specified. Azithromycin was better tolerated than erythromycin, and no adverse fetal outcomes were reported.

Azithromycin has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of fetotoxicity. There are no controlled data in human pregnancy. Azithromycin should only be given during pregnancy when benefit outweighs risk.

See references

Azithromycin Breastfeeding Warnings

Azithromycin is excreted into human milk. The manufacturer recommends that caution be used when administering azithromycin to nursing women.

In one lactating woman receiving azithromycin 500 mg/day, azithromycin milk concentration measured 1.3 and 2.8 mcg/mL 1 hour after the first dose and 30 hours after the third dose, respectively.

See references

References for pregnancy information

  1. Wehbeh HA, Ruggeirio RM, Shahem S, Lopez G, Ali Y "Single-dose azithromycin for Chlamydia in pregnant women." J Reprod Med 43 (1998): 509-14
  2. Bush MR, Rosa C "Azithromycin and erythromycin in the treatment of cervical chlamydial infection during pregnancy." Obstet Gynecol 84 (1994): 61-3
  3. "Sexually transmitted diseases treatment guidelines 2002." MMWR Morb Mortal Wkly Rep 51(RR-6) (2002): 1-77
  4. Adair CD, Gunter M, Stovall TG, McElroy G, Veille JC, Ernest JM "Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin." Obstet Gynecol 91 (1998): 165-8
  5. Donders GGG "Treatment of sexually transmitted bacterial diseases in pregnant women." Drugs 59 (2000): 477-85
  6. "Product Information. Zithromax (azithromycin)." Pfizer US Pharmaceuticals, New York, NY.

References for breastfeeding information

  1. "Product Information. Zithromax (azithromycin)." Pfizer US Pharmaceuticals, New York, NY.
  2. Kelsey JJ, Moser LR, Jennings JC, Munger MA "Presence of azithromycin breast milk concentrations: a case report." Am J Obstet Gynecol 170 (1994): 1375-6

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