Comparing Amitriptyline vs Cyclobenzaprine
Amitriptyline | Cyclobenzaprine |
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Amitriptyline | Cyclobenzaprine |
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Prescription only
Amitriptyline is an effective antidepressant but it may cause drowsiness initially and a withdrawal syndrome with abrupt discontinuation. It may be used off-label to treat other conditions such as... View more |
Prescription only
Cyclobenzaprine is a muscle relaxant that may be used short-term to treat muscle spasms caused by musculoskeletal conditions, in addition to rest and physical therapy. Sedation is a common side... View more |
Related suggestions Migraine
Fibromyalgia
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More about Amitriptyline | More about Cyclobenzaprine | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Amitriptyline has an average rating of 7.6 out of 10 from a total of 1778 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 16% reported a negative effect. |
Cyclobenzaprine has an average rating of 5.9 out of 10 from a total of 612 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 31% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: amitriptyline side effects in more detail. |
See also: cyclobenzaprine side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all amitriptyline prices |
View all cyclobenzaprine prices |
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Dosage Forms Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
N/A |
Amrix, Comfort Pac with Cyclobenzaprine | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
16 hours |
72 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 709 drugs are known to interact with amitriptyline:
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A total of 444 drugs are known to interact with cyclobenzaprine:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
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First Approval Date | |||||||||||||||||
April 07, 1961 |
August 26, 1977 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.