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Could you or a loved one be experiencing depression?

Medications for Depression

What is Depression:  Feelings of depression may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of us feel this way at one time or another for short periods. But true clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for an extended period of time.

Medications to treat Depression

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
amitriptyline / perphenazine N N X 1 review
9.0

Generic name: amitriptyline / perphenazine systemic

Brand names:  Duo-Vil, Etrafon, Etrafon Forte, Triavil

Drug class: psychotherapeutic combinations

For consumers: interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
armodafinil Off Label C 4 18 reviews
7.0

Generic name: armodafinil systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
atomoxetine Off Label C N 5 reviews
6.0

Generic name: atomoxetine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
brexpiprazole N X 27 reviews
7.0

Generic name: brexpiprazole systemic

Brand name:  Rexulti

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
Duo-Vil N N X Add review Rate

Generic name: amitriptyline / perphenazine systemic

Drug class: psychotherapeutic combinations

For consumers: interactions, side effects

 
Etrafon N N X Add review Rate

Generic name: amitriptyline / perphenazine systemic

Drug class: psychotherapeutic combinations

For consumers: interactions, side effects

 
Etrafon Forte N N X Add review Rate

Generic name: amitriptyline / perphenazine systemic

Drug class: psychotherapeutic combinations

For consumers: interactions, side effects

 
isocarboxazid C N X 3 reviews
9.0

Generic name: isocarboxazid systemic

Brand name:  Marplan

Drug class: monoamine oxidase inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts

 
Khedezla C N X Add review Rate

Generic name: desvenlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

 
L-Methylfolate Formula N N Add review Rate

Generic name: l-methylfolate systemic

Drug class: vitamins

For consumers: dosage, side effects

 
L-Methylfolate Forte N N Add review Rate

Generic name: l-methylfolate systemic

Drug class: vitamins

For consumers: dosage, side effects

 
levomilnacipran C N X 68 reviews
4.0

Generic name: levomilnacipran systemic

Brand name:  Fetzima

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
lisdexamfetamine Off Label C 2 X 6 reviews
6.0

Generic name: lisdexamfetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Off Label: Yes

 
Ludiomil B N X 2 reviews
6.0

Generic name: maprotiline systemic

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
maprotiline B N X 4 reviews
8.0

Generic name: maprotiline systemic

Brand name:  Ludiomil

Drug class: tetracyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Marplan C N X 3 reviews
9.0

Generic name: isocarboxazid systemic

Drug class: monoamine oxidase inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
phenelzine C N X 40 reviews
8.0

Generic name: phenelzine systemic

Brand name:  Nardil

Drug class: monoamine oxidase inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
protriptyline N N X 2 reviews
8.0

Generic name: protriptyline systemic

Brand name:  Vivactil

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Surmontil C N X 1 review
8.0

Generic name: trimipramine systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
thyroid desiccated Off Label A N Add review Rate

Generic name: thyroid desiccated systemic

Drug class: thyroid drugs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Tofranil-PM N N X Add review
9.0

Generic name: imipramine systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
tranylcypromine N N X 57 reviews
8.0

Generic name: tranylcypromine systemic

Brand name:  Parnate

Drug class: monoamine oxidase inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Triavil N N X Add review Rate

Generic name: amitriptyline / perphenazine systemic

Drug class: psychotherapeutic combinations

For consumers: interactions, side effects

 
trimipramine C N X 2 reviews
8.0

Generic name: trimipramine systemic

Brand name:  Surmontil

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Vivactil N N X 2 reviews
8.0

Generic name: protriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
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Topics under Depression

Alternative treatments for Depression

The following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression.

Learn more about Depression

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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