Pamelor Side Effects
Generic name: nortriptyline
Medically reviewed by Drugs.com. Last updated on Apr 10, 2023.
Note: This document contains side effect information about nortriptyline. Some dosage forms listed on this page may not apply to the brand name Pamelor.
Applies to nortriptyline: oral capsules and oral solution.
- Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need.h i Nortriptyline is not approved for use in pediatric patients.a (See Pediatric Use under Cautions.)
- In pooled data analyses, risk of suicidality was not increased in adults >24 years of age and apparently was reduced in adults ≥65 years of age with antidepressant therapy compared with placebo.h i
- Depression and certain other psychiatric disorders are themselves associated with an increased risk of suicide.h i j
- Appropriately monitor and closely observe all patients who are started on nortriptyline therapy for clinical worsening, suicidality, or unusual changes in behavior; involve family members and/or caregivers in this process.h i j (See Worsening of Depression and Suicidality Risk under Cautions.)
Side effects include:
For Healthcare Professionals
Applies to nortriptyline: compounding powder, oral capsule, oral solution.
Frequency not reported: Alteration in electroencephalogram (EEG) patterns, ataxia, dizziness, drowsiness, extrapyramidal symptoms, extremity paresthesia, headache, incoordination, mydriasis, numbness, peculiar taste, peripheral neuropathy, seizures, stroke, tingling, tremors[Ref]
Frequency not reported: Agitation, anxiety, confusional states with hallucinations, delusions, disorientation, exacerbation of psychosis, hypomania, increased/decreased libido, insomnia, nightmares, panic, restlessness, suicidal behaviors, suicidal ideation[Ref]
Frequency not reported: Abdominal cramps, black tongue, constipation, diarrhea, dry mouth, epigastric distress, gingivitis, nausea, paralytic ileus, parotid swelling, stomatitis, sublingual adenitis, tongue edema, vomiting[Ref]
Postmarketing reports: Brugada syndrome[Ref]
Frequency not reported: Blurred vision, disturbance of accommodation
Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion[Ref]
Frequency not reported: Cross sensitivity (with other tricyclic drugs)[Ref]
Frequency not reported: Increased risk of bone fractures[Ref]
Frequently asked questions
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More about Pamelor (nortriptyline)
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Related treatment guides
1. Product Information. Pamelor (nortriptyline). Sandoz Pharmaceuticals Corporation. 2002.
2. Cerner Multum, Inc. UK Summary of Product Characteristics.
3. Cerner Multum, Inc. Australian Product Information.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.