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Protriptyline Side Effects

Medically reviewed by Last updated on Jan 8, 2024.

Applies to protriptyline: oral tablet.


Oral route (Tablet)

In short-term studies, antidepressants increased the risk of suicidal thinking and behavior compared with placebo in children, adolescents, and young adults with psychiatric disorders, including major depressive disorder (MDD); there was not an increased risk of suicidality with antidepressants in adults older than 24 years and there was a decreased risk of suicidality in adults aged 65 years or older. The risk of suicidal thinking and behavior should be balanced with the clinical need for therapy and patients should be monitored closely; instruct families and caregivers to communicate any changes in behavior with the prescriber. Not approved for use in pediatric patients.

Serious side effects of Protriptyline

Along with its needed effects, protriptyline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking protriptyline:

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking protriptyline:

Symptoms of overdose

Other side effects of Protriptyline

Some side effects of protriptyline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to protriptyline: oral tablet.


The most commonly reported side effects were dry mouth, constipation, and blurred vision.[Ref]

Nervous system

Frequency not reported: Alteration in EEG patterns, ataxia, dizziness, drowsiness, extrapyramidal symptoms, extremity numbness, extremity paresthesia, extremity tingling, headache, incoordination, mydriasis, peripheral neuropathy, taste, seizures, stroke, tremors[Ref]


Frequency not reported: Agitation, anxiety, confusional states (particularly in the elderly) with hallucinations, delusions, disorientation, exacerbation of psychosis, hypomania, increased or decreased libido, insomnia, nightmares, panic, restlessness, suicidal behaviors, withdrawal symptoms[Ref]


Frequency not reported: Abdominal cramps, black tongue, constipation, diarrhea, dry mouth, epigastric distress, nausea, paralytic ileus, parotid swelling, tongue edema, stomatitis, sublingual adenitis, vomiting[Ref]


Frequency not reported: Arrhythmias, edema, flushing, general edema, myocardial infarction, heart block, hypertension, hypotension, orthostatic hypotension, palpitation, tachycardia[Ref]


Frequency not reported: Breast enlargement, delayed micturition, dilatation of the urinary tract, galactorrhea, impotence, nocturia, testicular swelling, urinary frequency, urinary retention[Ref]


Frequency not reported: Alopecia, face edema, itching, perspiration, petechia, photosensitization, skin rash, urticaria[Ref]


Frequency not reported: Drug fever, fatigue, hyperpyrexia, malaise, tinnitus, weakness[Ref]


Frequency not reported: Agranulocytosis, bone marrow depression, eosinophilia, leukopenia, purpura, thrombocytopenia[Ref]


Frequency not reported: Anorexia, elevation or depression of blood sugar levels, weight gain or loss[Ref]


Frequency not reported: Altered liver function, jaundice (simulating obstructive)[Ref]


Frequency not reported: Blurred vision, disturbance of accommodation[Ref]


Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion[Ref]


1. Product Information. Vivactil (protriptyline). Merck & Co., Inc. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.