Skip to Content

Trimipramine Dosage

Applies to the following strength(s): 25 mg ; 50 mg ; 100 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Depression

Outpatients:
Initial dose: 75 mg orally per day in divided doses
Maintenance dose: 50 to 150 mg orally per day
Maximum Dose: 200 mg orally per day

Hospitalized patients:
Initial dose: 100 mg orally per day in divided doses
Maintenance dose: 200 mg orally per day
Maximum Dose: 300 mg orally per day

Comments:
-The entire dose may be given at bedtime to improve patient compliance.

Use:
-Relief of symptoms of depression

Usual Geriatric Dose for Depression

Initial: 50 mg orally per day
Maintenance dose: 100 mg orally per day

Comments:
-Maintenance therapy is preferably administered as a single dose at bedtime.
-To minimize relapse, maintenance therapy should be continued for about three months.

Use:
-Relief of symptoms of depression

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution

Precautions

BOXED WARNING(S):
Suicidality and Antidepressant Drugs:
-Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of this drug or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need.
-Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. There was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
-Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber.
-This drug is not approved for use in pediatric patients.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:
-Prescriptions should be written for the smallest quantity consistent with good patient management, in order to reduce the risk of overdose.

Patient advice:
-This drug may initially impair alertness. Patients should be warned of the possible hazard when driving or operating machinery.

Hide