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Isocarboxazid Side Effects

In Summary

Commonly reported side effects of isocarboxazid include: dizziness and headache. Other side effects include: suicidal ideation, suicidal tendencies, drowsiness, sleep disorder, tremor, nausea, and orthostatic hypotension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to isocarboxazid: oral tablet

In addition to its needed effects, some unwanted effects may be caused by isocarboxazid. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking isocarboxazid:

Less common:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • cold sweats
  • confusion
  • difficult urination
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fear or nervousness
  • heavy feeling
  • increased need to urinate
  • passing urine more often
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • sudden jerky movements of the body
  • sweating
  • trembling or shaking of the hands or feet
  • trouble sitting still
Incidence not known:
  • Agitation
  • burning while urinating
  • change in consciousness
  • decrease in frequency of urination
  • decrease in urine volume
  • decreased urine output
  • depression
  • difficulty in passing urine (dribbling)
  • dizziness
  • false or unusual sense of well-being
  • headache
  • hostility
  • irritability
  • loss of bladder control
  • loss of consciousness
  • muscle twitching
  • nausea
  • need to keep moving
  • numbness or tingling of the hands, feet, or face
  • rapid weight gain
  • seeing, hearing, or feeling things that are not there
  • seizures
  • shakiness and unsteady walk
  • stupor
  • swelling of the face, ankles, or hands
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with isocarboxazid may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Constipation
  • dry mouth
Less common:
  • Decreased interest in sexual intercourse
  • drowsiness
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • relaxed and calm
  • sleepiness
  • sleeplessness
  • trouble sleeping
  • unable to sleep
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Incidence not known:
  • Black tongue
  • blurred vision
  • change in vision
  • impaired vision
  • increased sensitivity of the skin to sunlight
  • itching
  • raised, dark red, wart-like spots on the skin, especially when used on the face
  • redness or other discoloration of the skin
  • severe sunburn
  • skin rash

For Healthcare Professionals

Applies to isocarboxazid: oral tablet

Cardiovascular

Common (1% to 10%): Orthostatic hypotension, palpitations
Frequency not reported: Disturbances in cardiac rhythm[Ref]

Hypertensive crisis can occur during isocarboxazid therapy and is characterized by some or all of the following symptoms: occipital headache that may radiate frontally, palpitation, neck stiffness or soreness, nausea or vomiting, sweating that is sometimes accompanied by fever or cold, clammy skin, pupil dilatation, photophobia, tachycardia or bradycardia, and constricting chest pain. Intracranial bleeding, which can be fatal, has also been reported with the paradoxical increase in blood pressure. Hypertensive crises may be precipitated by concomitant administration of sympathomimetic drugs or related compounds or other MAO inhibitors. Ingestion of foods with a high concentration of tyramine or dopamine and excessive amounts of caffeine and chocolate may also cause a hypertensive crisis. Blood pressure should be monitored frequently in all patients and therapy discontinued immediately upon the occurrence of palpitation or frequent headaches, as these signs may be prodromal of a hypertensive crisis.[Ref]

Nervous system

Very common (10% or more): Dizziness (29%), headache (15%)
Common (1% to 10%): Drowsy, tremor, myoclonic jerks, paresthesia, forgetful, hyperactive, lethargy, sedation, syncope
Frequency not reported: Hyperreflexia, overactivity
Postmarketing reports: Akathisia, ataxia, coma, neuritis[Ref]

Gastrointestinal

Common (1% to 10%): Dry mouth, constipation, nausea, diarrhea
Frequency not reported: Vomiting
Postmarketing reports: Black tongue[Ref]

Ocular

Frequency not reported: Blurred vision
Postmarketing reports: Toxic amblyopia[Ref]

Musculoskeletal

Common (1% to 10%): Chills, heavy feeling
Frequency not reported: Muscle tremor[Ref]

Genitourinary

Common (1% to 10%): Urinary hesitancy, urinary frequency, impotence
Frequency not reported: Impairment of erection and ejaculation
Postmarketing reports: Dysuria, incontinence, urinary retention[Ref]

General

The most common adverse events were dizziness, headache, nausea, and dry mouth.[Ref]

Endocrine

Postmarketing reports: Impaired water secretion compatible with syndrome of inappropriate secretion of antidiuretic hormone (SIADH)[Ref]

Dermatologic

Common (1% to 10%): Sweating
Frequency not reported: Skin rashes
Postmarketing reports: Photosensitivity, spider telangiectases[Ref]

Renal

Frequency not reported: Difficulty in micturition[Ref]

Psychiatric

Hallucinations have been reported with high doses, but have disappeared with dose reduction or discontinuation of therapy.[Ref]

Common (1% to 10%): Insomnia, sleep disturbance, anxiety
Frequency not reported: Confusion, behavioral changes, suicidal ideation, suicidal behavior
Postmarketing reports: Hallucinations[Ref]

Other

Frequency not reported: Peripheral edema, fatigue, weakness[Ref]

Hematologic

Rare (less than 0.1%): Blood dyscrasias (purpura, granulocytopenia)
Postmarketing reports: Hematologic changes[Ref]

References

1. "Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for isocarboxazid may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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