Skip to Content
Could you or a loved one be experiencing depression?

Isocarboxazid Pregnancy and Breastfeeding Warnings

Isocarboxazid is also known as: Marplan

Isocarboxazid Pregnancy Warnings

Adequate animal studies have not been performed. There are no controlled data in human pregnancy. The molecular weight (about 231) is low enough that fetal exposure should be expected. The Collaborative Perinatal Project monitored 21 mother-child pairs exposed to monoamine oxidase inhibitors during the first trimester of pregnancy; one of which was exposed to isocarboxazid. An increased risk of malformation was observed, however details were not given. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Use should be avoided, especially during the first and last trimesters of pregnancy; this drug should be used during pregnancy only if clearly needed. US FDA pregnancy category: C

See references

Isocarboxazid Breastfeeding Warnings

Use is contraindicated. (UK) This drug should be used only if clearly needed. (US) Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: -Because of its low molecular weight, excretion into breast milk is expected.

See references

References for pregnancy information

  1. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):
  2. "Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References for breastfeeding information

  1. "Product Information. Marplan (isocarboxazid)" Roche Laboratories, Nutley, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.