Vicodin Alternatives Compared
| Vicodin | Methotrexate | Sulfasalazine |
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| Vicodin (acetaminophen / hydrocodone) | Methotrexate | Sulfasalazine |
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Prescription only
Vicodin is a combination narcotic analgesic that may be used short-term for the relief of moderate-to-moderately severe pain that is unrelieved by nonopioid analgesics, and also for the relief of a... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prescribed for Lymphocytic Colitis, Juvenile Rheumatoid Arthritis, Inflammatory Bowel Disease, Rheumatoid Arthritis, Ulcerative Colitis, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance... View more |
Related suggestions Rheumatoid Arthritis
Popular comparisons
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| More about Vicodin (acetaminophen / hydrocodone) | More about Methotrexate | More about Sulfasalazine | ||||||||||||||||
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| Ratings & Reviews | ||||||||||||||||||
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Vicodin has an average rating of 7.8 out of 10 from a total of 143 ratings on Drugs.com. 72% of reviewers reported a positive effect, while 13% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 277 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
Sulfasalazine has an average rating of 5.2 out of 10 from a total of 136 ratings on Drugs.com. 39% of reviewers reported a positive effect, while 45% reported a negative effect. |
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| Side Effects | ||||||||||||||||||
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See also: Vicodin side effects in more detail. |
Commonly reported side effects include:
See also: methotrexate side effects in more detail. |
Commonly reported side effects include:
See also: sulfasalazine side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all methotrexate prices |
View all sulfasalazine prices |
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| Dosage Form(s) Available | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
| Other acetaminophen / hydrocodone brands include: Xodol, Zyfrel | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | Azulfidine, Azulfidine EN-tabs | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
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3.8 hours |
15 hours |
10 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||
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High potential for abuse
Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 601 drugs are known to interact with Vicodin:
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A total of 642 drugs are known to interact with methotrexate:
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A total of 233 drugs are known to interact with sulfasalazine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
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| First Approval Date | ||||||||||||||||||
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January 07, 1983 |
December 07, 1953 |
June 20, 1950 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
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N/A |
N/A |
N/A |
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N/A |
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| Related Treatment Guide | ||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.