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Vicodin (acetaminophen / hydrocodone) Drug Interactions

A total of 565 drugs are known to interact with Vicodin (acetaminophen / hydrocodone).

  • 199 major drug interactions
  • 356 moderate drug interactions
  • 10 minor drug interactions

Show all medications in the database that may interact with Vicodin (acetaminophen / hydrocodone).

Check for interactions

Type in a drug name to check for interactions with Vicodin (acetaminophen / hydrocodone).

Most frequently checked interactions

View interaction reports for Vicodin (acetaminophen / hydrocodone) and the medicines listed below.

Vicodin (acetaminophen / hydrocodone) alcohol/food interactions

There is 1 alcohol/food interaction with Vicodin (acetaminophen / hydrocodone)

Vicodin (acetaminophen / hydrocodone) disease interactions

There are 20 disease interactions with Vicodin (acetaminophen / hydrocodone) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.