Simponi Alternatives Compared
| Simponi | Methotrexate | Sulfasalazine |
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| Simponi (golimumab) | Methotrexate | Sulfasalazine |
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Prescription only
Prescribed for Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Spondyloarthritis, Ulcerative Colitis. Simponi may also be used for purposes not listed in this medication guide. |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prescribed for Inflammatory Bowel Disease, Lymphocytic Colitis, Juvenile Rheumatoid Arthritis, Rheumatoid Arthritis, Ulcerative Colitis, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance... View more |
Related suggestions Rheumatoid Arthritis
Popular comparisons
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| More about Simponi (golimumab) | More about Methotrexate | More about Sulfasalazine | ||||||||||||||||||||||||
| Generic Status | ||||||||||||||||||||||||||
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No lower-cost generic available |
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| Ratings & Reviews | ||||||||||||||||||||||||||
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Simponi has an average rating of 6.1 out of 10 from a total of 106 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 32% reported a negative effect. |
Methotrexate has an average rating of 6.5 out of 10 from a total of 304 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect. |
Sulfasalazine has an average rating of 5.5 out of 10 from a total of 156 ratings on Drugs.com. 41% of reviewers reported a positive effect, while 42% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
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Common side effects include:
See also: Simponi side effects in more detail. |
Commonly reported side effects include:
See also: methotrexate side effects in more detail. |
Commonly reported side effects include:
See also: sulfasalazine side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Simponi prices |
View all methotrexate prices |
View all sulfasalazine prices |
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| Dosage Form(s) Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Other golimumab brands include: Simponi Aria | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | Azulfidine, Azulfidine EN-tabs | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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336 hours |
15 hours |
10 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 442 drugs are known to interact with Simponi:
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A total of 656 drugs are known to interact with methotrexate:
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A total of 247 drugs are known to interact with sulfasalazine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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April 24, 2009 |
December 07, 1953 |
June 20, 1950 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.