Simponi and Fatigue: What Users Say

• Pig...
• August 17, 2016

For Rheumatoid Arthritis "Was on Humira for 11 years, which stopped working. Enbrel, horrible reaction. Started Simponi in April. It took about 2 months to kick in, but now working great! Sleeping better than ever, have only had 2 days of minor pain. Only thing that is still challenging is the fatigue. Very happy with results and love the once a month injection."

• Mar...
• Taken for 1 to 6 months
• August 26, 2019

For Rheumatoid Arthritis "I came off Rituxan after several successful years of treatment for RA (almost in remission) when I experienced 12-18 months of chronic infection in my lungs and ears. Diagnosed at age 53, 17 years ago. Have had both knees replaced and have carpal tunnel pain in one thumb. At the same time as the infections, it was discovered I had a cat allergy. These two factors together meant my body could not get rid of the chest infections and ear infections because of the constant cat allergy creating stuffed-up conditions. #5 Simponi infusion in Sept to give it one last chance, but since #1 infusion was in April, I have developed finger movement and pain, bunions, RA flares in the second toe and a foot joint, plus fatigue has sucked the interest in life right out of me. I felt great for 10 days this month on a Prednisone burst, but am weaning off it next week. I do not have a lot of faith that Simponi will 'kick in' after 5 months and hope for something else soon that is more effective for me."

• Lin...
• Taken for 1 to 6 months
• May 14, 2023

For Rheumatoid Arthritis "I have been on every oral drug for treatment for RA. I then was prescribed Orencia subcutaneously for 2.5 years. I still had to use prednisone 15-25 mg on a regular basis when I worked. Orencia did not show any real change in my symptoms. I then changed to Simponi 50 mg subcutaneously monthly. I could feel a difference after the very first injection. After 3 weeks, my swelling and moderate to severe symptoms of RA improved. Following my second injection, I noticed an over 50% improvement in my fatigue. As of now, after my third injection, I can mostly claim I am improved by at least 80% of overall symptoms: morning stiffness, my pain, my energy levels. In closing, without trying to sound dramatic, I can confidently say Simponi 50 mg subcutaneously monthly has overall improved the quality of my life by 90%."

• Anonymous
• Taken for 1 to 6 months
• March 17, 2022

For Rheumatoid Arthritis "I started Simponi infusions. Just recently, my first infusion was fine, made me a bit tired, but no side effects and no effects at all. My second infusion was 3 weeks ago. I again was tired after the infusion, but I was more tired than usual. I started not feeling real great. The next day, I felt even worse. I believe every side effect that this drug has, I had: fever, cold chills, nausea, extremely fatigued, headache. My whole body has and still is swelled up 2 times more than normal, having trouble breathing. I then ended up with a sinus infection and then pneumonia. Let me say that I have been dealing with RA/Fibromyalgia for the past 23 years. I have been on everything and anything that is available. Suffice to say, nothing has worked for me. However, I never had any side effects to this magnitude with the others. I am glad this works for others and was really hoping to finally get some relief, but I guess my body is rejecting this medication, so I feel I had better listen to it."

• Anonymous
• Taken for 1 to 6 months
• October 12, 2022

For Rheumatoid Arthritis "This is terrible stuff. Made my RA worse. Caused side effects of extreme fatigue, muscle pains, psoriasis on my scalp and dermatitis, and my hair has been falling out. Also causing my lymph nodes to swell. It has been 3 months, so I am trying something else and will discontinue. Wish I never tried."

• LVe...
• Taken for 5 to 10 years
• October 17, 2022

For Rheumatoid Arthritis "Simponi has been the most effective biologic for me. I've used (infusions or injectable) Humira, Enbrel, Orencia, Remicade, and Simponi. I have been on Simponi 3 times as long as any other medication. Over 6 years of effectiveness. I take one 50 mg syringe monthly, and although I still struggle with fatigue, flares are managed as well as joint degeneration."

• Bar...
• February 9, 2023

For Psoriatic Arthritis "I have been taking Osimponi since November 2022 for psoriatic arthritis spondylitis. I have been experiencing chronic fatigue, shortness of breath, infections, low hemoglobin, dizzy spells, and high cholesterol. It has also made me sick every day to the point I can hardly eat due to chronic nausea. Will not be taking next month's injection. Horrendous experience."

• Cat...
• Taken for 1 to 6 months
• July 19, 2017

For Psoriatic Arthritis "Worked okay on aches and pains, but really messed with me mentally. Made me very depressed and socially withdrawn. I feel more fatigue and a lot of headaches."