Nicotine Alternatives Compared
| Nicotine | Bupropion | Varenicline |
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| Nicotine | Bupropion | Varenicline |
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Prescription and OTC
Prescribed for Smoking Cessation. Nicotine may also be used for purposes not listed in this medication guide. |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Prescription only
Prescribed for Smoking Cessation, Dry Eye Disease. Varenicline may also be used for purposes not listed in this medication guide. |
Related suggestions Smoking Cessation
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| More about Nicotine | More about Bupropion | More about Varenicline | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Nicotine has an average rating of 7.6 out of 10 from a total of 202 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 16% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2904 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
Varenicline has an average rating of 8.4 out of 10 from a total of 1721 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 9% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Nicotine side effects |
View all Bupropion side effects |
View all Varenicline side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Nicotine prices |
View all Bupropion prices |
View all Varenicline prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Commit, Habitrol, Leader Nicotine Polacrilex, Nicoderm CQ, Nicorette, Nicorette DS, Nicotrol Inhaler, Nicotrol NS | Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | Champix, Tyrvaya | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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4 hours |
30 hours |
24 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 90 drugs are known to interact with Nicotine:
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A total of 559 drugs are known to interact with Bupropion:
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A total of 65 drugs are known to interact with Varenicline:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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January 13, 1984 |
December 30, 1985 |
May 10, 2006 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Wellbutrin
Wellbutrin (bupropion) is used to treat major depressive disorder and seasonal affective disorder ...
Wellbutrin XL
Wellbutrin XL is used for depression, major depressive disorder, seasonal affective disorder
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Chantix
Chantix is a smoking cessation medicine used with behavior modification and counseling to help you ...
Wellbutrin SR
Wellbutrin SR is used for depression, major depressive disorder
Tyrvaya
Tyrvaya is a prescription nasal spray used to treat the signs and symptoms of dry eye disease ...
Nicorette
Nicorette (nicotine) gum and lozenges are used as an aid in smoking cessation. Includes Nicorette ...
Zyban
Zyban helps people stop smoking by reducing cravings and other withdrawal effects. Learn about side ...
Forfivo XL
Forfivo XL (bupropion) is used to treat major depressive disorder. Includes Forfivo XL side ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.