Nicotine Alternatives Compared
| Nicotine | Bupropion | Topiramate |
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| Nicotine | Bupropion | Topiramate |
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Prescription and OTC
Prescribed for Smoking Cessation. Nicotine may also be used for purposes not listed in this medication guide. |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Prescription only
Topiramate may be prescribed either alone or in combination with other medications for the treatment of certain types of epilepsy, or it may be given for the prevention of migraines. Drowsiness is a... View more |
Related suggestions Smoking Cessation
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| More about Nicotine | More about Bupropion | More about Topiramate | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Nicotine has an average rating of 7.6 out of 10 from a total of 202 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 16% reported a negative effect. |
Bupropion has an average rating of 7.0 out of 10 from a total of 2913 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 20% reported a negative effect. |
Topiramate has an average rating of 6.3 out of 10 from a total of 1337 ratings on Drugs.com. 50% of reviewers reported a positive effect, while 28% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||||||||||
View all Nicotine side effects |
View all Bupropion side effects |
View all Topiramate side effects |
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| Drug Class | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Nicotine prices |
View all Bupropion prices |
View all Topiramate prices |
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| Dosage Forms | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Commit, Habitrol, Leader Nicotine Polacrilex, Nicoderm CQ, Nicorette, Nicorette DS, Nicotrol Inhaler, Nicotrol NS | Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | Eprontia, Qudexy XR, Topamax, Trokendi XR | ||||||||||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||||||||||
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4 hours |
30 hours |
56 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 91 drugs are known to interact with Nicotine:
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A total of 560 drugs are known to interact with Bupropion:
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A total of 291 drugs are known to interact with Topiramate:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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January 13, 1984 |
December 30, 1985 |
December 24, 1996 |
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| WADA Class View classifications | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient Resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.