Nicotine Alternatives Compared
| Nicotine | Bupropion | Varenicline |
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| Nicotine | Bupropion | Varenicline |
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Prescription and OTC
Prescribed for Smoking Cessation. Nicotine may also be used for purposes not listed in this medication guide. |
Prescription only
Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more |
Prescription only
Prescribed for Smoking Cessation, Dry Eye Disease. Varenicline may also be used for purposes not listed in this medication guide. |
Related suggestions Smoking Cessation
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| More about Nicotine | More about Bupropion | More about Varenicline | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Nicotine has an average rating of 7.8 out of 10 from a total of 202 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 14% reported a negative effect. |
Bupropion has an average rating of 7.1 out of 10 from a total of 2898 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 20% reported a negative effect. |
Varenicline has an average rating of 8.6 out of 10 from a total of 1717 ratings on Drugs.com. 83% of reviewers reported a positive effect, while 9% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Nicotine prices |
View all Bupropion prices |
View all Varenicline prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Commit, Habitrol, Leader Nicotine Polacrilex, Nicoderm CQ, Nicorette, Nicorette DS, Nicotrol Inhaler, Nicotrol NS | Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL | Champix, Tyrvaya | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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4 hours |
30 hours |
24 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 31 drugs are known to interact with Nicotine:
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A total of 526 drugs are known to interact with Bupropion:
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A total of 8 drugs are known to interact with Varenicline:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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January 13, 1984 |
December 30, 1985 |
May 10, 2006 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.