Hydromorphone Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Hydromorphone	Tramadol	Gabapentin	Enter another drug to compare

Hydromorphone

Tramadol

Gabapentin

Prescription only

Hydromorphone is a morphine-like pain-relieving medicine that may be given to relieve severe pain that is not relieved by other pain-relieving treatments. It carries a high risk of respiratory... View more

Prescription only

Tramadol is a strong opioid pain relieving medication that may be used to treat moderate to severe general and nerve-related pain. Tramadol may be habit-forming and misuse can cause addiction... View more

Prescription only

Gabapentin is an anticonvulsant with pain-relieving effects that may be used to treat certain seizure disorders or relieve nerve pain. Common side effects include dizziness or drowsiness and it may... View more

More about Hydromorphone

More about Tramadol

More about Gabapentin

Ratings & Reviews

Hydromorphone has an average rating of 8.0 out of 10 from a total of 448 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 15% reported a negative effect.

Tramadol has an average rating of 7.0 out of 10 from a total of 1877 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 23% reported a negative effect.

Gabapentin has an average rating of 7.1 out of 10 from a total of 2574 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 21% reported a negative effect.

View all 448 reviews

View all 1877 reviews

View all 2574 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (8.7%)
Drowsiness (2.9%)
Vomiting (2.5%)
Addiction (2.2%)
Hallucinations (2.2%)
Constipation (2.0%)
Itching (1.8%)

View all Hydromorphone side effects

Nausea (6.4%)
Withdrawal (5.8%)
Headaches (4.6%)
Constipation (3.7%)
Dizziness (3.7%)
Anxiety (3.6%)
Depression (3.2%)

View all Tramadol side effects

Dizziness (7.3%)
Drowsiness (7.0%)
Anxiety (5.7%)
Tiredness (4.0%)
Weight gain (3.8%)
Insomnia (3.7%)
Memory loss (3.4%)

View all Gabapentin side effects

Drug Class

Opioids (narcotic analgesics)

Opioids (narcotic analgesics)

Gamma-aminobutyric acid analogs

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	100 each
Strength	4 mg
Per unit^*	$0.30
Cost^*	$30.37

View all Hydromorphone prices

Quantity	9 tablet
Strength	50 mg
Per unit^*	$1.34
Cost^*	$12.06

View all Tramadol prices

Quantity	100 each
Strength	300 mg
Per unit^*	$0.24 - $0.33
Cost^*	$23.69 - $33.10

View all Gabapentin prices

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Dosage Forms

Injectable solution
Oral liquid
Oral tablet
Oral tablet, extended release
Rectal suppository

Oral capsule, extended release
Oral liquid
Oral tablet
Oral tablet, extended release

Oral capsule
Oral solution
Oral tablet
Oral tablet, extended release

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

3.1 hours

5.2 hours

6 hours

CSA Schedule ¹ View glossary of CSA terms

High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 440 drugs are known to interact with Hydromorphone:

124 major drug interactions (493 brand and generic names)
315 moderate drug interactions (1360 brand and generic names)
1 minor drug interactions (3 brand and generic names)

A total of 712 drugs are known to interact with Tramadol:

318 major drug interactions (1226 brand and generic names)
391 moderate drug interactions (1571 brand and generic names)
3 minor drug interactions (7 brand and generic names)

A total of 270 drugs are known to interact with Gabapentin:

28 major drug interactions (148 brand and generic names)
232 moderate drug interactions (1027 brand and generic names)
10 minor drug interactions (52 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more

Alcohol can increase the nervous system side effects of traMADol such as dizziness, drowsiness, and... View more

Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness... View more

Disease Interactions

First Approval Date

December 07, 1992

March 03, 1995

December 30, 1993

WADA Class View classifications

S7 - Narcotics

S7 - Narcotics

N/A

More Information

Patient Resources

Hydromorphone uses

Tramadol uses

Gabapentin uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Hydromorphone Alternatives Compared

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