Comparing Flexeril vs Baclofen

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Flexeril (cyclobenzaprine)	Baclofen	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Flexeril (cyclobenzaprine)	Baclofen	Enter another drug to compare
Prescription only Flexeril is a muscle relaxant that may be used short-term in addition to rest and physical therapy to treat muscle spasms caused by musculoskeletal conditions. Sedation is a common side effect... View more	Prescription only Baclofen relieves muscle spasms associated with multiple sclerosis and spinal cord injury or disease, but its use is limited by its ability to cause sedation and increase seizure risk. Prescribed for... View more	Related suggestions Muscle Spasm (Involuntary Hypertonicity) Cyclobenzaprine Tizanidine Methocarbamol Soma Zanaflex Diazepam Popular comparisons Flexeril vs gabapentin Flexeril vs tramadol Flexeril vs methocarbamol Flexeril vs baclofen Flexeril vs tizanidine Flexeril vs metaxalone
More about Flexeril (cyclobenzaprine)	More about Baclofen
Ratings & Reviews
Flexeril has an average rating of 6.1 out of 10 from a total of 237 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 27% reported a negative effect.	Baclofen has an average rating of 7.0 out of 10 from a total of 447 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 24% reported a negative effect.
View all 237 reviews	View all 447 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Drowsiness (19.8%) Dry mouth (9.3%) Tiredness (5.5%) Depression (3.0%) Dizziness (3.0%) Sleepy (3.0%) Hallucinations (2.5%) View all Flexeril side effects	Drowsiness (8.7%) Dizziness (6.3%) Muscle spasms (4.3%) Nausea (3.8%) Tiredness (3.8%) Headaches (3.4%) Sleepy (3.4%) View all Baclofen side effects
Drug Class
Skeletal muscle relaxants	Skeletal muscle relaxants
Generic Availability
Lower cost generic approved	Lower cost generic
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
N/A	Intrathecal solution Oral liquid Oral tablet
Brand Names
Other cyclobenzaprine brands include: Amrix, Comfort Pac with Cyclobenzaprine	Fleqsuvy, Gablofen, Lioresal, Lioresal Intrathecal, Lyvispah, Ozobax, Ozobax DS
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
72 hours	6.8 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
B Category B No proven risk in humans See the full pregnancy warnings document.	C Category C Risk cannot be ruled out See the full pregnancy warnings document.
Drug Interactions
A total of 451 drugs are known to interact with Flexeril: 92 major drug interactions (471 brand and generic names) 353 moderate drug interactions (1412 brand and generic names) 6 minor drug interactions (13 brand and generic names)	A total of 369 drugs are known to interact with Baclofen: 27 major drug interactions (146 brand and generic names) 341 moderate drug interactions (1374 brand and generic names) 1 minor drug interactions (2 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Alcohol can increase the nervous system side effects of cyclobenzaprine such as dizziness... View more	Alcohol can increase the nervous system side effects of baclofen such as dizziness, drowsiness, and... View more
Disease Interactions
Cardiovascular disease Anticholinergic effects	Renal dysfunction Autonomic dysreflexia Psychoses Seizure disorders
First Approval Date
August 26, 1977	November 22, 1977
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group En español
Patient Resources
Flexeril uses	Baclofen uses Advanced reading
Professional Resources
Prescribing information	Monograph (AHFS) Prescribing information
Related Treatment Guide
Muscle Spasm Sciatica	Alcohol Withdrawal Cervical Dystonia Chronic Spasticity Cerebral Spasticity Muscle Spasm Spinal Spasticity Cluster-Tic Syndrome Dystonia Hiccups Huntington's Disease Migraine Prevention Muscle Twitching Neuralgia Periodic Limb Movement Disorder Spasticity Temporomandibular Joint Disorder Trigeminal Neuralgia show all

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Comparing Flexeril vs Baclofen

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Comparing Flexeril vs Baclofen

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