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Celecoxib Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Celecoxib Buprenex Tramadol
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Celecoxib Buprenex (buprenorphine) Tramadol
Prescription only

Celecoxib is a COX-2 specific NSAID that has a lower propensity for gastrointestinal side effects than many other NSAIDs; however, it still may increase the risk of serious cardiovascular thrombotic... View more

Prescription only

Buprenex is a potent analgesic that should be only used to treat moderate to severe pain under strict conditions when other analgesics have proved inadequate. Sedation is the main side effect and it... View more

Prescription only

Tramadol is a strong pain relief medicine effective for both general and nerve-related pain. Tramadol can cause dependence and use may be limited by side effects such as nausea and... View more

More about Celecoxib More about Buprenex (buprenorphine) More about Tramadol
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

Celecoxib has an average rating of 6.9 out of 10 from a total of 257 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 23% reported a negative effect.

Buprenex has an average rating of 8.4 out of 10 from a total of 6 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 20% reported a negative effect.

Tramadol has an average rating of 6.8 out of 10 from a total of 1789 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 25% reported a negative effect.

View all 257 reviews

View all 6 reviews

View all 1789 reviews

Drug Class
Side Effects

Commonly reported side effects include:

  • diarrhea
  • hypertension
  • abnormal hepatic function tests

See also: celecoxib side effects in more detail.

See also: Buprenex side effects in more detail.

Commonly reported side effects include:

  • pruritus
  • agitation
  • anxiety
  • constipation
  • diarrhea
  • hallucination
  • nausea
  • tremor
  • vomiting
  • diaphoresis
  • show all 10

See also: tramadol side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 10 capsule
Dosage 200 mg
Per Unit* $2.07 - $2.27
Cost* $20.65 - $22.67

View all celecoxib prices

Quantity 5 mL
Dosage 0.3 mg/mL
Per Unit* $17.87
Cost* $89.37

View all Buprenex prices and generic prices

Quantity 9 tablet
Dosage 50 mg
Per Unit* $1.29
Cost* $11.59

View all tramadol prices

Get free Discount Card

Get free Discount Card

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Dosage Form(s) Available
  • Oral capsule
  • Injectable solution
  • Oral capsule, extended release
  • Oral liquid
  • Oral tablet
  • Oral tablet, extended release
Brand Names
Celebrex, Elyxyb Other buprenorphine brands include: Belbuca, Butrans, Sublocade ConZip, Qdolo, Tramadol Hydrochloride ER
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

11 hours

48 hours

5.2 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
3
Moderate abuse potential

Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4
Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
Pregnancy Category
C
Category C Risk cannot be ruled out

Prior To 30 Weeks Gestation

D
Category D Positive evidence of risk

Starting At 30 Weeks Gestation

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 393 drugs are known to interact with celecoxib:

  • 63 major drug interactions (329 brand and generic names)
  • 326 moderate drug interactions (1305 brand and generic names)
  • 4 minor drug interactions (12 brand and generic names)

A total of 662 drugs are known to interact with Buprenex:

  • 201 major drug interactions (686 brand and generic names)
  • 457 moderate drug interactions (1843 brand and generic names)
  • 4 minor drug interactions (9 brand and generic names)

A total of 648 drugs are known to interact with tramadol:

  • 303 major drug interactions (1132 brand and generic names)
  • 343 moderate drug interactions (1433 brand and generic names)
  • 2 minor drug interactions (5 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Using buprenorphine together with other medications that also cause central nervous system... View more
  • Alcohol can increase the nervous system side effects of traMADol such as dizziness, drowsiness, and... View more
Disease Interactions
First Approval Date

October 29, 2014

N/A

August 29, 2011
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A
More Information
Patient resources

N/A
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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