Comparing Prednisone vs Rituximab

For Inflammatory Conditions: My mother has been on prednisone for almost four years for polumyalgia/rheumatica. We found out recently that the reason she was in such horrible back pain and could hardly walk was the extended use of prednisone. The MRI showed she had actual cracks in her spine. We are still in shock. This cannot be reversed. Even though people feel fine and really on top of the world the end result is devastating. So now we are dealing with even more pain not even associated with Polymyalgia. She will never recover from this. Everyone is different, but please look at the cons of the medicine before taking. Beware!

For Inflammatory Conditions: I took prednisone 20mg for 3 years for Autoimmune Hepatitis and it definitely helped bring down my AST/ALT. I even saw regression of cirrhosis (by fibroscan). Side effects included increased appetite, weight gain (20lb max), moon face, hair started growing curly instead of straight, more severe infections (especially GI), and trouble regulating emotions. I didn't complain though, as I knew it was keeping me alive!

For Rheumatoid Arthritis: Rituxan was prescribed for my RA about 8-10 years ago and allowed me to continue working full time putting the max away for retirement. Some fatigue occasionally but no joint pain. After retirement, the combination of allergy to a new huge Maine Coon cat causing chronic congestion AND the suppression of my autoimmune system by years of Rituxan - led to repeated chest, ear and sinus infections. After many tests, allergy shots and several consultations with specialists, the Rituxan was discontinued. Now (2 years later) no more infections but the RA is up and raging again. New hand and finger damage as well as bunions and flares on toes that had never occurred before. My doctor is waiting for a fifth Simponi infusion in 2-3 weeks before moving on to another drug. Simponi has done nothing. What is there for me to take at this point?

For Rheumatoid Arthritis: I am sat having my 10th cycle, 1st infusion of rituximab. Sleepy while having infusions otherwise no side effects. Previously I could not walk or look after myself. I had no quality of life. Now enjoying life with a little help. My rheumatoid hasn't gone completely but is more manageable to deal with. Not pain, or inflammation free but much better than I was. I know the side effects can sound very scary but discuss this with your consultant or specialist nurse. They are very helpful, very informative and understanding. They do not know the long term side effects of this drug but more importantly I can now live a life as before I was just existing. Try not to be daunted, ask, ask, ask and don't be afraid to try new drugs they might help