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Medications for Pemphigus Vulgaris

About Pemphigus Vulgaris

Pemphigus vulgaris is the most common subtype of pemphigus, an autoimmune blister disorder of the mucous membranes and skin. The signs of pemphigus vulgaris are fragile blisters usually starting within the mouth and later may develop on the skin.

The body’s own immune system attacks the surface of cells (keratinocytes) that are within the epidermis layer of the skin. This causes the skin cells to separate from each other which creates the thin walled, fluid filled blisters. The blisters are rarely seen intact in the mouth as they burst easily leaving painful erosions that are slow to to heal. In pemphigus vulgaris the lesions usually form on the mucous membranes, most commonly the mouth but may also include oesophagus, genitals, conjunctiva, urethra and anus. Pemphigus vulgaris may progress over several months from affecting the mucous membranes to also include blisters on the skin. The lesions can be extremely painful, can be slow to heal, and if there is significant areas affected then infection and fluid loss can become life threatening.

Pemphigus vulgaris is a chronic illness that usually requires active treatment to control symptoms then maintenance treatment to prevent a relapse or flare of the condition.

Drugs used to treat Pemphigus Vulgaris

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Rituxan Rate Add review
Rx C N

Generic name: rituximab systemic

Drug class: antirheumatics, CD20 monoclonal antibodies

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

rituximab Rate Add review
Rx C N

Generic name: rituximab systemic

Brand name:  Rituxan

Drug class: antirheumatics, CD20 monoclonal antibodies

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.