Comparing Nucynta ER vs Xtampza ER

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nucynta ER (tapentadol)	Xtampza ER (oxycodone)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nucynta ER (tapentadol)	Xtampza ER (oxycodone)	Enter another drug to compare
Prescription only Prescribed for Diabetic Peripheral Neuropathy, Pain. Nucynta ER may also be used for purposes not listed in this medication guide.	Prescription only Prescribed for Chronic Pain, Pain. Xtampza ER may also be used for purposes not listed in this medication guide.	Related suggestions Pain Tramadol Gabapentin Ibuprofen Acetaminophen Oxycodone Tylenol
More about Nucynta ER (tapentadol)	More about Xtampza ER (oxycodone)
Ratings & Reviews
Nucynta ER has an average rating of 7.2 out of 10 from a total of 81 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 19% reported a negative effect.	Xtampza ER has an average rating of 3.9 out of 10 from a total of 169 ratings on Drugs.com. 24% of reviewers reported a positive effect, while 62% reported a negative effect.
View all 81 reviews	View all 169 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Nausea (7.4%) Constipation (4.9%) Dizziness (4.9%) Drowsiness (4.9%) Insomnia (4.9%) Tiredness (4.9%) Pain (3.7%) View all Nucynta ER side effects	Nausea (11.8%) Headaches (7.7%) Dizziness (4.7%) Nightmares (4.7%) Pain (4.7%) Weight gain (4.1%) Withdrawal (4.1%) View all Xtampza ER side effects
Drug Class
Opioids (narcotic analgesics)	Opioids (narcotic analgesics)
Generic Availability
No lower cost generic approved	No lower cost generic approved
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral tablet, extended release	N/A
Brand Names
Other tapentadol brands include: Nucynta	Other oxycodone brands include: Dazidox, Endocodone, ETH-Oxydose, Oxaydo, OxyContin, Oxydose, Oxyfast, Roxicodone, RoxyBond View more
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
4 hours	5.6 hours
CSA Schedule ¹ View glossary of CSA terms
2 High potential for abuse Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.	2 High potential for abuse Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	N Category N Not classified See the full pregnancy warnings document.
Drug Interactions
A total of 422 drugs are known to interact with Nucynta ER: 186 major drug interactions (793 brand and generic names) 235 moderate drug interactions (1177 brand and generic names) 1 minor drug interactions (3 brand and generic names)	A total of 624 drugs are known to interact with Xtampza ER: 214 major drug interactions (778 brand and generic names) 407 moderate drug interactions (1578 brand and generic names) 3 minor drug interactions (7 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Alcohol can increase the nervous system side effects of tapentadol such as dizziness, drowsiness... View more	Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more
Disease Interactions
Impaired GI motility Infectious diarrhea Prematurity Acute alcohol intoxication Drug dependence Hypotension Intracranial pressure Respiratory depression Gastrointestinal obstruction Liver disease Renal dysfunction Seizure disorders Urinary retention Biliary tract disease	Impaired GI motility Infectious diarrhea Prematurity Acute alcohol intoxication Drug dependence Hypotension Intracranial pressure Respiratory depression Gastrointestinal obstruction Adrenal insufficiency Liver disease Renal dysfunction Seizure disorders Urinary retention Arrhythmias Biliary tract disease
First Approval Date
August 25, 2011	April 26, 2016
WADA Class View classifications
N/A	S7 - Narcotics
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group En español	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group En español
Patient Resources
Nucynta ER uses Advanced reading	Xtampza ER uses
Professional Resources
Prescribing information	Prescribing information
Related Treatment Guide
Diabetic Peripheral Neuropathy Pain	Chronic Pain Pain

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

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Comparing Nucynta ER vs Xtampza ER

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Comparing Nucynta ER vs Xtampza ER

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