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Roxicodone

Generic name: oxycodoneox-i-KOE-done ]
Drug class: Opioids (narcotic analgesics)

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 15, 2023.

What is Roxicodone?

Roxicodone is an opioid pain medication sometimes called a narcotic.

Roxicodone is strong prescription pain medicine used to treat moderate to severe pain. It is used to manage pain when other treatments such as non-opioid pain medicines are unable to control the pain or you cannot tolerate alternate treatments.

Patients with chronic pain should have their dosage given on an around-the-clock basis to prevent the reoccurrence of pain rather than treating the pain after it has occurred.

Roxicodone is supplied as an immediate-release tablet and is available in 5 mg, 15 mg, and 30 mg strengths.

Changing brands of oxycodone from immediate-release tablets to extended-release tablets must be accompanied by close observation checking for signs of excessive drowsiness or slow breathing.

Warnings

You should not use Roxicodone if you have severe asthma or breathing problems, a bowel blockage, or have narrowing of the stomach or intestines.

MISUSE OF ROXICODONE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking Roxicodone during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use Roxicodone with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Before taking this medicine

You should not use Roxicodone if you are allergic to oxycodone, or if you have:

You should not use Roxicodone unless you are already using a similar opioid medicine and are tolerant to it.

Most brands of oxycodone are not approved for use in people under 18.

To make sure Roxicodone is safe for you, tell your doctor if you have:

If you use oxycodone while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

Ask a doctor before using Roxicodone if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

How should I use Roxicodone?

Take Roxicodone exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use Roxicodone in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more oxycodone .

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Take Roxicodone with food.

Swallow the tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, or dissolve a tablet.

Never crush or break a tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. This can cause in death.

You should not stop using Roxicodone suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature, away from heat, moisture, and light. Keep track of your medicine. Roxicodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using Roxicodone accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

What happens if I miss a dose?

Since Roxicodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Roxicodone could be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.

What should I avoid while using Roxicodone?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or operating machinery until you know how Roxicodone will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Avoid medication errors. Always check the brand and strength of oxycodone you get from the pharmacy.

Roxicodone side effects

Get emergency medical help if you have signs of an allergic reaction to Roxicodone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Oxycodone can slow or stop your breathing, and death may occur. A person caring for you should give naloxone and/or seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders.

Common Roxicodone side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Roxicodone?

You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.

Oxycodone can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete and many other drugs may affect Roxicodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Any drug that is classified as an "opioid" can cause constipation. Examples of commonly prescribed opioids that may cause this side effect include morphine, tramadol, fentanyl, methadone, hydrocodone, codeine and oxycodone. Continue reading

Immediate-release oxycodone has a half-life of just under 4 hours which means the pain-relieving effects of one dose will be gone within 6 to 24 hours, but it can remain detectable in saliva, urine, and hair for much longer. In saliva, oxycodone is detectable within minutes of taking it and lasts for up to 48 hours (2 days). Oxycodone is detectable in urine within 1 to 3 hours and will stay detectable for 1 to 4 days. Like most other opioids, oxycodone is detectable in hair for up to 90 days. Continue reading

How long opioid withdrawal lasts depends on the opioid you have been taking and whether it is a short-acting or long acting opioid.

If you have been using a short-acting opioid, acute opioid withdrawal lasts 4 to 10 days, with withdrawal symptoms starting 8 to 24 hours after last use.

If you have been using a long-acting opioid, acute opioid withdrawal lasts 10 to 20 days, with withdrawal symptoms starting 12 to 48 hours after last use. Continue reading

Oxycodone (also known as Oxy IR) and Oxycontin both contain oxycodone, but the main difference is that Oxycontin is the brand name of a long-acting form of oxycodone. Oxycontin releases oxycodone slowly and continuously over 12 hours and only needs to be given twice a day. Oxycodone is shorter-acting, with an average half-life of 3.2 hours, which means that half the dose of oxycodone is eliminated in 3.2 hours, which is why it is usually given four to six times a day to provide all-day pain relief. Oxycodone is usually given for acute pain, such as that following surgery or trauma, whereas Oxycontin may be given for chronic or long-term pain, such as that caused by cancer. Oxycontin should only be considered in those with chronic severe pain that have already found a trial of oxycodone to be beneficial. Continue reading

Immediate-release oxycodone starts to work quickly, within 10 to 30 minutes, but it may take up to 1 hour for it to be fully absorbed, and the full effects reached. Food can delay how quickly oxycodone takes to work, but not how much is absorbed. Continue reading

Withdrawal from oxycodone is likely to happen to people who have taken oxycodone consistently or misused oxycodone. Common symptoms of withdrawal include:

  • Anxiety
  • Cravings for oxycodone – these are one of the main symptoms that drive relapse
  • Diarrhea
  • Fast heartbeat
  • High blood pressure
  • Muscle aches
  • Nausea or vomiting
  • Sleep disturbances/Insomnia
  • Stomach cramps
  • Sweating.
Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Roxicodone only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.