Januvia Alternatives Compared
| Januvia (sitagliptin) | Rybelsus (semaglutide) | Metformin |
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| Januvia (sitagliptin) | Rybelsus (semaglutide) | Metformin |
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Prescription only
Januvia is a DPP-4 inhibitor that is used in addition to other medications for the treatment of type 2 diabetes. Rarely, it may cause joint pain, skin reactions, pancreatitis, or an allergic... View more |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Prescription only
Metformin improves how the body responds to insulin and it is used to treat type 2 diabetes. Taste disturbances, diarrhea, and other stomach-related side effects are common side effects. Metformin is... View more |
Related suggestions Type 2 Diabetes
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| More about Januvia (sitagliptin) | More about Rybelsus (semaglutide) | More about Metformin | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Januvia has an average rating of 4.5 out of 10 from a total of 139 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 53% reported a negative effect. |
Rybelsus has an average rating of 6.5 out of 10 from a total of 309 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect. |
Metformin has an average rating of 6.8 out of 10 from a total of 660 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
View all Januvia side effects |
View all Rybelsus side effects |
View all Metformin side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Rybelsus prices |
View all Metformin prices |
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| Dosage Forms | ||||||||||||||||||
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| Brand Names | ||||||||||||||||||
| Other sitagliptin brands include: Brynovin, Zituvio | Other semaglutide brands include: Ozempic, Wegovy | Glumetza | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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12.4 hours |
168 hours |
4.5 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 298 drugs are known to interact with Januvia:
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A total of 275 drugs are known to interact with Rybelsus:
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A total of 380 drugs are known to interact with Metformin:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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October 16, 2006 |
September 20, 2019 |
March 03, 1995 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.