Generic name: SITAGLIPTIN PHOSPHATE 25mg
Dosage form: tablet, film coated
Medically reviewed on February 9, 2018.
The recommended dose of JANUVIA is 100 mg once daily. JANUVIA can be taken with or without food.
Recommendations for Use in Renal Impairment
For patients with an estimated glomerular filtration rate [eGFR] greater than or equal to 45 mL/min/1.73 m2 to less than 90 mL/min/1.73 m2, no dosage adjustment for JANUVIA is required.
For patients with moderate renal impairment (eGFR greater than or equal to 30 mL/min/1.73 m2 to less than 45 mL/min/1.73 m2), the dose of JANUVIA is 50 mg once daily.
For patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m2) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of JANUVIA is 25 mg once daily. JANUVIA may be administered without regard to the timing of dialysis.
Because there is a need for dosage adjustment based upon renal function, assessment of renal function is recommended prior to initiation of JANUVIA and periodically thereafter. There have been postmarketing reports of worsening renal function in patients with renal impairment, some of whom were prescribed inappropriate doses of sitagliptin.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: dipeptidyl peptidase 4 inhibitors