Brynovin

Generic name: sitagliptin [ SIT-a-GLIP-tin ]
Other brand names of sitagliptin include: Brynovin, Januvia, Zituvio
Drug class: Dipeptidyl peptidase 4 inhibitors

Medically reviewed by Drugs.com on Aug 5, 2025. Written by Cerner Multum.

What is Brynovin?

Brynovin is used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus (not for type 1 diabetes).

Brynovin may also be used for purposes not listed in this medication guide.

Brynovin side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Stop taking Brynovin and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, with or without vomiting.

Brynovin may cause serious side effects. Call your doctor at once if you have:

• severe or ongoing pain in your joints;

• a severe skin reaction-- itching, blisters, breakdown of the outer layer of skin;

• severely low blood sugar--extreme weakness, confusion, tremors, sweating, fast heartbeats, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions); or

• kidney problems or symptoms of heart failure--swelling, urinating less, rapid weight gain, feeling tired or short of breath.

Common side effects of Brynovin may include:

• low blood sugar (if you also use insulin or another oral diabetes medication);

• cold symptoms such as stuffy or runny nose, sneezing, sore throat; or

• headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Call your doctor if you have symptoms of heart failure: shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.

Stop taking Brynovin and call your doctor if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, with or without vomiting.

Before taking this medicine

You should not use Brynovin if you are allergic to it or any of its ingredients.

Tell your doctor if you have or have ever had:

• heart problems such as heart failure;

• pancreatitis;

• high triglycerides (a type of fat in the blood);

• gallstones;

• alcoholism; or

• kidney disease (or if you are on dialysis).

It is not known if Brynovin will harm an unborn baby. Follow your doctor's instructions about using Brynovin if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I take Brynovin?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Brynovin is usually taken once per day with or without food. Follow your doctor's instructions.

Measure liquid medicine with the supplied measuring device (not a kitchen spoon).

Blood sugar can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals.

Low blood sugar (hypoglycemia) can make you feel very hungry, dizzy, irritable, or shaky. To quickly treat hypoglycemia, eat or drink hard candy, crackers, raisins, fruit juice, or non-diet soda. Your doctor may prescribe glucagon injection in case of severe hypoglycemia.

Tell your doctor if you have frequent symptoms of high blood sugar (hyperglycemia) such as increased thirst or urination. Ask your doctor before changing your medication dosage.

Your blood sugar will need to be checked on a regular basis, and you may need other medical tests including checking your kidney function.

You may be given other medications to help with your condition. Keep taking these medicines for as long as your doctor has prescribed.

Your treatment may also include diet, exercise, weight control, and special medical care.

Store the tablets at room temperature away from moisture and heat.

Store the oral solution in the refrigerator. Protect from light, heat and do not freeze.

Brynovin may be used for only a certain number of months after opening. Throw away any medicine not used within that time. Talk to your pharmacist if you have any questions.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Brynovin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Brynovin?

When you start or stop taking Brynovin, your doctor may need to adjust the doses of other medicines you use on a regular basis. Tell your doctor about all your other medicines, especially:

• insulin or oral diabetes medicine.

Many drugs can affect your blood sugar and may also affect Brynovin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use. Not all possible interactions are listed here.

Frequently asked questions

• Can Victoza and Januvia be used together?

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2025 Cerner Multum, Inc. Version: 14.01.