Comparing Januvia vs Rybelsus
Januvia | Rybelsus |
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Januvia (sitagliptin) | Rybelsus (semaglutide) |
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Prescription only
Januvia is a DDP-4 inhibitor that is used in addition to other medications for the treatment of type 2 diabetes. Rarely, it may cause joint pain, skin reactions, pancreatitis, or an allergic... View more |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Related suggestions Diabetes, Type 2
Popular comparisons
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More about Januvia (sitagliptin) | More about Rybelsus (semaglutide) | ||||||||
Ratings & Reviews | |||||||||
Januvia has an average rating of 4.7 out of 10 from a total of 138 ratings on Drugs.com. 31% of reviewers reported a positive effect, while 50% reported a negative effect. |
Rybelsus has an average rating of 6.3 out of 10 from a total of 253 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 26% reported a negative effect. |
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Drug Class | |||||||||
Side Effects | |||||||||
See also: Januvia side effects in more detail. |
See also: Rybelsus side effects in more detail. |
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Generic Availability | |||||||||
Pricing and Coupons * Prices are without insurance | |||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Rybelsus prices |
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Dosage Forms Available | |||||||||
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Brand Names | |||||||||
Other sitagliptin brands include: Zituvio | Other semaglutide brands include: Ozempic, Wegovy | ||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||
12.4 hours |
168 hours |
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CSA Schedule ** View glossary of terms | |||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||
Category B
No proven risk in humans
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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Drug Interactions | |||||||||
A total of 288 drugs are known to interact with Januvia:
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A total of 265 drugs are known to interact with Rybelsus:
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Alcohol/Food/Lifestyle Interactions | |||||||||
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Disease Interactions | |||||||||
First Approval Date | |||||||||
October 16, 2006 |
September 20, 2019 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||
N/A |
N/A |
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More Information | |||||||||
Patient resources | |||||||||
Professional Resources | |||||||||
Related Treatment Guide | |||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.